外源性抗坏血酸在豚鼠中抗坏血酸-2-硫酸盐组织状态中的作用。

Role of exogenous ascorbic acid in tissue status of ascorbic acid-2-sulphate in guinea pigs.

作者信息

Pillai G R, Indira M, Vijayammal P L

机构信息

Department of Biochemistry, University of Kerala, Trivandrum, India.

出版信息

Indian J Exp Biol. 1991 Dec;29(12):1127-30.

PMID:1816097

Abstract

Guinea pigs were given ascorbic acid orally in two doses; a low and a high dose. The tissue levels of ascorbic acid-2-sulphate was estimated in these animals after 15 days of feeding and a subsequent deprivation period of 15 days. The specific activity of the enzymes ascorbic acid sulphotransferase and ascorbic acid-2-sulphate sulphohydrolase was studied. During higher ascorbic acid intake, the activity of ascorbic acid sulphotransferase was increased, whereas ascorbic acid-2-sulphate sulphohydrolase showed a decreased activity. But when ascorbic acid intake was lowered or ceased, the activity of the above enzymes showed a reverse pattern. Possible reasons for the lack of antiscorbutic activity of ascorbic acid-2-sulphate in guinea pigs is discussed.

摘要

给豚鼠口服两种剂量的抗坏血酸，即低剂量和高剂量。在喂食15天以及随后15天的剥夺期后，测定这些动物体内抗坏血酸-2-硫酸盐的组织水平。研究了抗坏血酸磺基转移酶和抗坏血酸-2-硫酸盐硫酸水解酶的比活性。在抗坏血酸摄入量较高时，抗坏血酸磺基转移酶的活性增加，而抗坏血酸-2-硫酸盐硫酸水解酶的活性降低。但当抗坏血酸摄入量降低或停止时，上述酶的活性呈现相反的模式。讨论了豚鼠中抗坏血酸-2-硫酸盐缺乏抗坏血病活性的可能原因。