Kasai T, Ishikawa Y, Inoue K, Tsujimura M, Hasegawa T
Department of Food Science, Faculty of Bioindustry, Tokyo University of Agriculture, Hokkaido, Japan.
Int J Vitam Nutr Res. 1995;65(1):36-9.
The antiscorbutic activity of 6-bromo-6-deoxy-L-ascorbic acid (I) in guinea pigs was compared to that of ascorbic acid (AsA). The growth test results in guinea pigs did not show any significant difference between the body weight increase in the respective 2 groups given compound (I) and that in the group given AsA. Scorbutic guinea pigs were found to completely recover from the disease after administration of the compound (I). There were no significant differences in the plasma alkaline phosphatase activity and the hydroxyproline content in the tibia between the group given compound (I) and that given AsA. The total vitamin C contents in the various tissues were similar in the 2 groups given compound (I) and the C-deficient group but they were lower than the levels for the group given AsA. It was shown that antiscorbutic activity was characteristic of compound (I) and it was almost equal to the effect of AsA.
将6-溴-6-脱氧-L-抗坏血酸（I）在豚鼠体内的抗坏血病活性与抗坏血酸（AsA）进行了比较。豚鼠生长试验结果表明，给予化合物（I）的两组与给予AsA的组在体重增加方面没有显著差异。发现患坏血病的豚鼠在给予化合物（I）后完全康复。给予化合物（I）的组与给予AsA的组在血浆碱性磷酸酶活性和胫骨羟脯氨酸含量方面没有显著差异。给予化合物（I）的两组与维生素C缺乏组各组织中的总维生素C含量相似，但低于给予AsA组的水平。结果表明，抗坏血病活性是化合物（I）的特性，且其效果几乎与AsA相同。
