Mascarenhas A F
Dept. of Surgery, St. John's Medical College Hospital, Bangalore, India.
Infection. 1991 Nov-Dec;19(6):456-8. doi: 10.1007/BF01726465.
Early studies in which a higher incidence of wound infection and septic complications in biliary surgery was found demonstrated the need for antibiotic prophylaxis. In two studies, one retrospective and one prospective, the role of prophylactic antibiotics in biliary surgery was studied in "at risk" and "no risk" groups of patients. Twenty-eight percent of "no risk" patients had a positive bile culture. It was concluded that a single dose of 1 g cefotaxime, administered upon induction of anaesthesia, is a safe and effective prophylactic regimen in biliary surgery.
早期研究发现，胆道手术中伤口感染和脓毒症并发症的发生率较高，这表明需要进行抗生素预防。在两项研究中，一项为回顾性研究，一项为前瞻性研究，对“有风险”和“无风险”患者组中预防性抗生素在胆道手术中的作用进行了研究。28%的“无风险”患者胆汁培养呈阳性。得出的结论是，麻醉诱导时给予1克头孢噻肟单剂量，是胆道手术中一种安全有效的预防方案。
