与胆管癌相关的遗传和表观遗传变化：从DNA甲基化到微小RNA
Genetic and epigenetic changes associated with cholangiocarcinoma: from DNA methylation to microRNAs.
作者信息
Stutes Monique, Tran Steven, DeMorrow Sharon
机构信息
Division of Research and Education, Scott & White Hospital, Temple, TX 76504, USA.
出版信息
World J Gastroenterol. 2007 Dec 28;13(48):6465-9. doi: 10.3748/wjg.v13.i48.6465.
Abstract
Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholangiocarcinoma.
摘要
胆管癌是起源于肝内和肝外胆管的恶性上皮性肝肿瘤。人们对这种疾病的分子发展了解甚少，并且几乎没有有效的治疗选择。因此，预后很差。遗传和表观遗传变化在人类细胞向恶性细胞的肿瘤转化中起着不可或缺的作用。本综述总结了一些较为普遍的遗传改变（通过微小RNA表达）和表观遗传变化（特定基因启动子的高甲基化），这些被认为与胆管癌的致癌过程有关。
相似文献
1
Genetic and epigenetic changes associated with cholangiocarcinoma: from DNA methylation to microRNAs.
World J Gastroenterol. 2007 Dec 28;13(48):6465-9. doi: 10.3748/wjg.v13.i48.6465.
2
Role of epigenetic alterations in cholangiocarcinoma.
J Hepatobiliary Pancreat Surg. 2006;13(4):274-9. doi: 10.1007/s00534-005-1055-3.
3
Epigenetic regulation in the carcinogenesis of cholangiocarcinoma.
Int J Biochem Cell Biol. 2015 Oct;67:110-4. doi: 10.1016/j.biocel.2015.06.012. Epub 2015 Jun 19.
4
Epigenetic alterations associated with cholangiocarcinoma (review).
Oncol Rep. 2009 Aug;22(2):227-32.
5
Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway.
Hepatology. 2014 Feb;59(2):544-54. doi: 10.1002/hep.26721. Epub 2013 Dec 24.
6
Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas.
Arch Pathol Lab Med. 2007 Jun;131(6):923-30. doi: 10.5858/2007-131-923-MPOMCI.
7
Promoter methylation and loss of coding exons of the fragile histidine triad (FHIT) gene in intrahepatic cholangiocarcinomas.
Liver Int. 2005 Dec;25(6):1202-8. doi: 10.1111/j.1478-3231.2005.01174.x.
8
Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar cholangiocarcinoma.
Oncol Rep. 2011 Feb;25(2):443-51. doi: 10.3892/or.2010.1089. Epub 2010 Dec 9.
9
Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes.
Oncogene. 2008 Jan 10;27(3):378-86. doi: 10.1038/sj.onc.1210648. Epub 2007 Jul 9.
10
Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma.
Cancer Lett. 2005 Jan 20;217(2):213-9. doi: 10.1016/j.canlet.2004.06.020.
引用本文的文献
1
Biliary Tract Cancers: Treatment Updates and Future Directions in the Era of Precision Medicine and Immuno-Oncology.
Front Oncol. 2021 Nov 15;11:768009. doi: 10.3389/fonc.2021.768009. eCollection 2021.
2
Cholangiocarcinoma and liver transplantation: What we know so far?
World J Gastrointest Pathophysiol. 2021 Sep 22;12(5):84-105. doi: 10.4291/wjgp.v12.i5.84.
3
CASC2/miR-24/miR-221 modulates the TRAIL resistance of hepatocellular carcinoma cell through caspase-8/caspase-3.
Cell Death Dis. 2018 Feb 23;9(3):318. doi: 10.1038/s41419-018-0350-2.
4
A six-microRNA set as prognostic indicators for bile duct cancer.
Int J Clin Exp Med. 2015 Oct 15;8(10):17261-70. eCollection 2015.
5
Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Sci Rep. 2015 Nov 5;5:16294. doi: 10.1038/srep16294.
6
ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth.
Sci Rep. 2014 Nov 4;4:6899. doi: 10.1038/srep06899.
7
Emerging insights into the role of microRNAs in the pathogenesis of cholangiocarcinoma.
Gene Expr. 2014;16(2):93-9. doi: 10.3727/105221614X13919976902174.
8
MicroRNAs in biliary diseases.
World J Gastroenterol. 2012 Nov 21;18(43):6189-96. doi: 10.3748/wjg.v18.i43.6189.
9
Mutual regulation between microRNA-373 and methyl-CpG-binding domain protein 2 in hilar cholangiocarcinoma.
World J Gastroenterol. 2012 Aug 7;18(29):3849-61. doi: 10.3748/wjg.v18.i29.3849.
10
Genetic profiling of intrahepatic cholangiocarcinoma.
Curr Opin Gastroenterol. 2012 May;28(3):266-72. doi: 10.1097/MOG.0b013e3283523c7e.
本文引用的文献
1
Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes.
Oncogene. 2008 Jan 10;27(3):378-86. doi: 10.1038/sj.onc.1210648. Epub 2007 Jul 9.
2
Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer.
Curr Opin Mol Ther. 2007 Jun;9(3):231-41.
3
Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas.
Arch Pathol Lab Med. 2007 Jun;131(6):923-30. doi: 10.5858/2007-131-923-MPOMCI.
4
Abnormal DNA methylation, epigenetics, and prostate cancer.
Front Biosci. 2007 May 1;12:4254-66. doi: 10.2741/2385.
5
mir-29 regulates Mcl-1 protein expression and apoptosis.
Oncogene. 2007 Sep 13;26(42):6133-40. doi: 10.1038/sj.onc.1210436. Epub 2007 Apr 2.
6
Cancer epigenomics: DNA methylomes and histone-modification maps.
Nat Rev Genet. 2007 Apr;8(4):286-98. doi: 10.1038/nrg2005. Epub 2007 Mar 6.
7
Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Gastroenterology. 2007 Jan;132(1):384-96. doi: 10.1053/j.gastro.2006.10.037. Epub 2006 Nov 7.
8
The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.
J Biol Chem. 2007 Mar 16;282(11):8256-64. doi: 10.1074/jbc.M607712200. Epub 2007 Jan 12.
9
Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression.
Cancer Res. 2006 Nov 1;66(21):10517-24. doi: 10.1158/0008-5472.CAN-06-2130.
10
Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States.
Liver Int. 2006 Nov;26(9):1047-53. doi: 10.1111/j.1478-3231.2006.01350.x.
Zotero 插件