对微小RNA在胆管癌发病机制中作用的新见解。
Emerging insights into the role of microRNAs in the pathogenesis of cholangiocarcinoma.
作者信息
Haga Hiroaki, Yan Irene, Takahashi Kenji, Wood Joseph, Patel Tushar
机构信息
Mayo Clinic, Jacksonville, FL, USA.
出版信息
Gene Expr. 2014;16(2):93-9. doi: 10.3727/105221614X13919976902174.
Abstract
The microRNAs (miRNAs) are small noncoding RNAs that are potent regulators of gene expression and can regulate several diverse biological functions. This minireview provides an overview of recent studies that have examined the role and involvement of miRNAs in cholangiocarcinomas. These studies provide evidence for deregulated expression of miRNA and are providing new insights into the potential contribution of these in the pathogenesis of cholangiocarcinoma.
摘要
微小RNA（miRNA）是一类小的非编码RNA，是基因表达的强效调节因子，可调节多种不同的生物学功能。本综述概述了近期研究，这些研究探讨了miRNA在胆管癌中的作用和参与情况。这些研究为miRNA表达失调提供了证据，并为其在胆管癌发病机制中的潜在作用提供了新的见解。
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