Enev Valentin S, Drescher Martina, Mulzer Johann
Institut für Organische Chemie, Währingerstrasse 38, A-1090 Wien, Austria.
Org Lett. 2008 Feb 7;10(3):413-6. doi: 10.1021/ol7027338. Epub 2007 Dec 28.
The synthesis of the highly substituted cis-decalin core of branimycin has been accomplished. A catalytic copper mediated SN2' opening of oxabicycle 7 with Grignard reagent and ring-closing metathesis served as key transformations.
布拉米星高度取代的顺式十氢化萘核心的合成已经完成。铜催化下，氧杂双环7与格氏试剂发生SN2'开环反应以及闭环复分解反应作为关键转化步骤。
