Liu Fei, Kohlmeier Sean, Wang Cun-Yu
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Cell Signal. 2008 Jun;20(6):999-1009. doi: 10.1016/j.cellsig.2007.11.011. Epub 2007 Nov 28.
Wnt proteins are a family of secreted proteins that regulate many aspects of cellular functions. The discovery that mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, could positively and negatively affect bone mass in humans generated an enormous amount of interest in the possible role of the Wnt signaling pathway in skeletal biology. Over the last decade, considerable progress has been made in determining the role of the canonical Wnt signaling pathway in various aspects of skeletal development. Furthermore, recent evidence indicates the important role of non-canonical Wnt signaling in skeletal development. In this review we discuss the current understanding of the role of Wnt signaling in chondrogenesis, osteoblastogenesis, and osteoclastogenesis.
Wnt蛋白是一类分泌蛋白，可调节细胞功能的多个方面。低密度脂蛋白受体相关蛋白5（一种假定的Wnt共受体）的突变可对人类骨量产生正向和负向影响，这一发现引发了人们对Wnt信号通路在骨骼生物学中可能作用的极大兴趣。在过去十年中，在确定经典Wnt信号通路在骨骼发育各个方面的作用方面取得了相当大的进展。此外，最近的证据表明非经典Wnt信号在骨骼发育中具有重要作用。在这篇综述中，我们讨论了目前对Wnt信号在软骨形成、成骨细胞生成和破骨细胞生成中作用的理解。
