Cagigi Alberto, Nilsson Anna, De Milito Angelo, Chiodi Francesca
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 16, S-17177 Stockholm, Sweden.
Vaccine. 2008 Jun 6;26(24):3016-25. doi: 10.1016/j.vaccine.2007.11.063. Epub 2007 Dec 17.
Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological memory. The molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions. This review focuses on B cell damage and antibody responses in HIV-1-infected patients during vaccination studies with viral and bacterial antigens. In addition novel data indicate that B cell activation may be at the basis of impaired immune responses.
诱导广泛的HIV-1中和抗体应是有效HIV-1疫苗的主要目标。然而，在HIV-1感染期间B细胞会受到严重损害，记忆B细胞丧失，血清学记忆下降。必须进一步明确导致B细胞损伤的分子事件，以便选择能够保留B细胞功能的疫苗成分。本综述重点关注在使用病毒和细菌抗原进行疫苗接种研究期间，HIV-1感染患者的B细胞损伤和抗体反应。此外，新数据表明B细胞活化可能是免疫反应受损的基础。
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