作为慢性免疫激活结果的过早B细胞衰老。
Premature B-cell senescence as a consequence of chronic immune activation.
作者信息
Palma Paolo, Rinaldi Stefano, Cotugno Nicola, Santilli Veronica, Pahwa Savita, Rossi Paolo, Cagigi Alberto
机构信息
a University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children's Hospital; Rome, Italy.
出版信息
Hum Vaccin Immunother. 2014;10(7):2083-8. doi: 10.4161/hv.28698.
Abstract
Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.
摘要
健康老年人的免疫系统与处于慢性免疫激活状态的年轻人的免疫系统之间的相似特征正逐渐被观察到。这引发了一种假说，即慢性免疫激活可能导致免疫系统过早衰老。在此，我们通过比较健康衰老过程中B细胞发生的变化与年轻个体慢性免疫激活过程中发生的变化来剖析这一理论。此外，我们还讨论了这些变化如何影响或预测免疫功能受损个体对疫苗接种的反应。
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