N-(4-羟基苯基)视黄酰胺通过抑制端粒酶和细胞周期诱导人胶质母细胞瘤细胞分化，以增加其对干扰素-γ诱导凋亡的敏感性。

N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.

作者信息

Janardhanan Rajiv, Banik Naren L, Ray Swapan K

机构信息

Division of Neurology, Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, P.O. Box 250606, Charleston, SC 29425, USA.

出版信息

Cancer Lett. 2008 Mar 8;261(1):26-36. doi: 10.1016/j.canlet.2007.11.016.

DOI:10.1016/j.canlet.2007.11.016

PMID:18164543

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103940/

Abstract

Glioblastoma is the most malignant and prevalent brain tumor in humans. It is composed of heterogenic abnormal astroglial cells that avoid differentiation, maintain proliferation, and hardly commit apoptosis. N-(4-Hydroxyphenyl)retinamide (4-HPR) induced astrocytic differentiation and increased sensitivity to interferon-gamma (IFN-gamma) for apoptosis in human glioblastoma A172, LN18, and SNB19 cells. Combination of 4-HPR and IFN-gamma significantly inhibited human telomerase reverse transcriptase (hTERT), cyclin dependent kinase 2 (CDK2), and survivin to up-regulate caspase-8, caspase-9, and caspase-3 for increasing apoptosis in all glioblastoma cell lines. Hence, combination of 4-HPR and IFN-gamma should be considered for controlling growth of different human glioblastoma cells.

摘要

胶质母细胞瘤是人类最恶性且最常见的脑肿瘤。它由异质性异常星形胶质细胞组成，这些细胞逃避分化、维持增殖且几乎不发生凋亡。N-(4-羟基苯基)视黄酸（4-HPR）诱导人胶质母细胞瘤A172、LN18和SNB19细胞发生星形胶质细胞分化，并增加对干扰素-γ（IFN-γ）诱导凋亡的敏感性。4-HPR与IFN-γ联合使用可显著抑制人端粒酶逆转录酶（hTERT）、细胞周期蛋白依赖性激酶2（CDK2）和生存素，上调半胱天冬酶-8、半胱天冬酶-9和半胱天冬酶-3，从而增加所有胶质母细胞瘤细胞系中的凋亡。因此，应考虑将4-HPR与IFN-γ联合使用来控制不同人胶质母细胞瘤细胞的生长。

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N-(4-羟基苯基)视黄酰胺通过抑制端粒酶和细胞周期诱导人胶质母细胞瘤细胞分化，以增加其对干扰素-γ诱导凋亡的敏感性。

N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.

作者信息

Janardhanan Rajiv, Banik Naren L, Ray Swapan K

机构信息

Division of Neurology, Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, P.O. Box 250606, Charleston, SC 29425, USA.

出版信息

Cancer Lett. 2008 Mar 8;261(1):26-36. doi: 10.1016/j.canlet.2007.11.016.

DOI:10.1016/j.canlet.2007.11.016

PMID:18164543

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103940/

Abstract

摘要

N-(4-羟基苯基)视黄酰胺通过抑制端粒酶和细胞周期诱导人胶质母细胞瘤细胞分化，以增加其对干扰素-γ诱导凋亡的敏感性。

N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.

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N-(4-羟基苯基)视黄酰胺通过抑制端粒酶和细胞周期诱导人胶质母细胞瘤细胞分化，以增加其对干扰素-γ诱导凋亡的敏感性。

N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.

作者信息

机构信息

出版信息