Vader Gerben, Medema René H, Lens Susanne M A
Department of Medical Oncology, University Medical Center, 3584 CG Utrecht, Netherlands.
J Cell Biol. 2006 Jun 19;173(6):833-7. doi: 10.1083/jcb.200604032. Epub 2006 Jun 12.
During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex.
在有丝分裂过程中，染色体乘客复合体（CPC）协调着高度不同的过程，如染色体排列、组蛋白修饰和胞质分裂。该复合体的正确且及时的定位是精确控制CPC酶核心——极光激酶B的关键。我们讨论了CPC成员在整个细胞分裂过程中指导该复合体动态定位的分子机制。此外，我们总结了CPC上发生的翻译后修饰，并讨论了它们在调节这种有丝分裂复合体的定位和功能中的作用。
