Crespo D, Cos S, Fernandez-Viadero C, Gonzalez C
Department of Anatomy, Faculty of Medicine, University of Cantabria, Santander, Spain.
Neurosci Lett. 1991 Dec 9;133(2):253-6. doi: 10.1016/0304-3940(91)90582-e.
We report the occurrence of neuronal degeneration in the supraoptic nucleus of the hypothalamus of prepubertal female rats as a consequence of ovariectomy followed by estrogen deprivation (OVX-EB). In contrast, no degenerating neurons were observed in ovariectomized rats treated with estrogens (OVX + EB) or sham-operated animals. The altered neurons in the OVX-EB group presented a cytoplasm with dilation of the rough endoplasmic reticulum lumen. The nuclear envelope also appeared dilated. There was mitochondrial swelling with disintegrated cristae, while lysosomes appeared intact. The cell nucleus showed a pattern of chromatin condensation and a nucleolus hardly distinguishable from the nucleoplasm. The neuronal alterations reported here may be due to altered gene expression in the cell nucleus resulting from induced hormonal loss during early postnatal development.
我们报告了青春期前雌性大鼠下丘脑视上核中神经元变性的发生情况，这是卵巢切除术后雌激素剥夺（OVX-EB）的结果。相比之下，在接受雌激素治疗的去卵巢大鼠（OVX + EB）或假手术动物中未观察到变性神经元。OVX-EB组中改变的神经元呈现出细胞质，其粗面内质网腔扩张。核膜也出现扩张。线粒体肿胀，嵴解体，而溶酶体似乎完好无损。细胞核显示出染色质凝聚的模式，核仁与核质几乎难以区分。此处报道的神经元改变可能是由于出生后早期发育过程中诱导的激素丧失导致细胞核中基因表达改变所致。
