Cho Il Jin, Ahn Ji Yun, Kim Suna, Choi Myung Sook, Ha Tae Youl
Division of Food Function Research, Korea Food Research Institute, 46-1 Baekhyun-Dong, Bundang-Gu, Songnam-Si, Kyunggi-Do 463-746, Republic of Korea.
Biochem Biophys Res Commun. 2008 Feb 29;367(1):190-4. doi: 10.1016/j.bbrc.2007.12.140. Epub 2007 Dec 31.
We investigated the hypolipidemic effect of resveratrol focused on the mRNA expression and hepatic HMG-CoA reductase (HMGR) activity in hamsters fed a high-fat diet. Male Syrian Golden hamsters were fed a high-fat diet containing 0.025% fenofibrate or 0.025% resveratrol for 8 weeks. The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group. These results indicate that dietary resveratrol reduces serum cholesterol by down-regulating hepatic HMGR mRNA expression in hamsters fed a high-fat diet.
我们以高脂饮食喂养的仓鼠为研究对象，聚焦于白藜芦醇对mRNA表达及肝脏3-羟基-3-甲基戊二酰辅酶A还原酶（HMGR）活性的影响，来研究其降血脂作用。雄性叙利亚金黄地鼠被喂食含0.025%非诺贝特或0.025%白藜芦醇的高脂饮食8周。白藜芦醇喂养组的血清总胆固醇和甘油三酯浓度显著低于对照组。含白藜芦醇的饮食显著降低了载脂蛋白B、脂蛋白(a)和胆固醇酯转运蛋白（CETP）的浓度，但提高了载脂蛋白A-I水平及载脂蛋白A-I/载脂蛋白B比值。白藜芦醇组肝脏组织中的胆固醇和甘油三酯含量显著低于对照组。实时定量PCR分析显示，白藜芦醇组的HMGR mRNA表达显著低于对照组。这些结果表明，在高脂饮食喂养的仓鼠中，饮食中的白藜芦醇通过下调肝脏HMGR mRNA表达来降低血清胆固醇。
