Wen Shi Wu, Chen Xi-Kuan, Rodger Marc, White Ruth Rennicks, Yang Qiuying, Smith Graeme N, Sigal Ronald J, Perkins Sherry L, Walker Mark C
OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada.
Am J Obstet Gynecol. 2008 Jan;198(1):45.e1-7. doi: 10.1016/j.ajog.2007.06.067.
The objective of the study was to evaluate the association between folic acid supplementation in early second trimester and the risk of developing preeclampsia.
We carried out a prospective cohort study between October 2002-December 2005. We recruited women who had their prenatal care visit (12-20 weeks' gestation) at the Ottawa Hospital and Kingston General Hospital. All charts for participants with a diagnosis of preeclampsia were audited and blindly adjudicated by 4 study investigators to validate the diagnosis.
A total of 2951 pregnant women were included in the final analysis. Supplementation of multivitamins containing folic acid was associated with increased serum folate (on average 10.51 micromol/L), decreased plasma homocysteine (on average 0.39 micromol/L), and reduced risk of preeclampsia (adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75).
Supplementation of multivitamins containing folic acid in the second trimester is associated with reduced risk of preeclampsia.
本研究的目的是评估孕中期早期补充叶酸与发生先兆子痫风险之间的关联。
我们在2002年10月至2005年12月期间开展了一项前瞻性队列研究。我们招募了在渥太华医院和金斯顿综合医院进行产前检查（妊娠12 - 20周）的女性。所有诊断为先兆子痫的参与者的病历均由4名研究调查员进行审核和盲法判定，以验证诊断。
共有2951名孕妇纳入最终分析。补充含叶酸的多种维生素与血清叶酸水平升高（平均10.51微摩尔/升）、血浆同型半胱氨酸水平降低（平均0.39微摩尔/升）以及先兆子痫风险降低相关（校正比值比，0.37；95%置信区间，0.18 - 0.75）。
孕中期补充含叶酸的多种维生素与先兆子痫风险降低相关。
