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寄养青年的精神药物使用模式。

Psychotropic medication patterns among youth in foster care.

作者信息

Zito Julie M, Safer Daniel J, Sai Devadatta, Gardner James F, Thomas Diane, Coombes Phyllis, Dubowski Melissa, Mendez-Lewis Maria

机构信息

Department of Pharmaceutical Health Services Research, University of Maryland, Baltimore, MD 21201, USA.

出版信息

Pediatrics. 2008 Jan;121(1):e157-63. doi: 10.1542/peds.2007-0212.

Abstract

CONTEXT

Studies have revealed that youth in foster care covered by Medicaid insurance receive psychotropic medication at a rate > 3 times that of Medicaid-insured youth who qualify by low family income. Systematic data on patterns of medication treatment, particularly concomitant drugs, for youth in foster care are limited.

OBJECTIVE

The purpose of this work was to describe and quantify patterns of psychotropic monotherapy and concomitant therapy prescribed to a randomly selected, 1-month sample of youth in foster care who had been receiving psychotropic medication. METHODS. Medicaid data were accessed for a July 2004 random sample of 472 medicated youth in foster care aged 0 through 19 years from a southwestern US state. Psychotropic medication treatment data were identified by concomitant pattern, frequency, medication class, subclass, and drug entity and were analyzed in relation to age group; gender; race or ethnicity; International Classification of Diseases, Ninth Revision, psychiatric diagnosis; and physician specialty.

RESULTS

Of the foster children who had been dispensed psychotropic medication, 41.3% received > or = 3 different classes of these drugs during July 2004, and 15.9% received > or = 4 different classes. The most frequently used medications were antidepressants (56.8%), attention-deficit/hyperactivity disorder drugs (55.9%), and antipsychotic agents (53.2%). The use of specific psychotropic medication classes varied little by diagnostic grouping. Psychiatrists prescribed 93% of the psychotropic medication dispensed to youth in foster care. The use of > or = 2 drugs within the same psychotropic medication class was noted in 22.2% of those who were given prescribed drugs concomitantly.

CONCLUSIONS

Concomitant psychotropic medication treatment is frequent for youth in foster care and lacks substantive evidence as to its effectiveness and safety.

摘要

背景

研究表明,享受医疗补助保险的寄养青年接受精神药物治疗的比例比因家庭收入低而符合条件的医疗补助保险青年高出3倍多。关于寄养青年药物治疗模式,特别是联合用药的数据有限。

目的

本研究旨在描述和量化随机抽取的、正在接受精神药物治疗的1个月寄养青年样本中精神药物单一疗法和联合疗法的模式。方法:获取了美国西南部一个州2004年7月随机抽取的472名0至19岁接受药物治疗的寄养青年的医疗补助数据。通过联合用药模式、频率、药物类别、亚类和药物实体确定精神药物治疗数据,并针对年龄组、性别、种族或族裔、《国际疾病分类(第九版)》精神科诊断以及医生专业进行分析。

结果

在已配发精神药物的寄养儿童中,41.3%在2004年7月接受了≥3种不同类别的此类药物治疗,15.9%接受了≥4种不同类别的治疗。最常用的药物是抗抑郁药(56.8%)、注意力缺陷/多动障碍药物(55.9%)和抗精神病药物(53.2%)。特定精神药物类别的使用在诊断分组中差异不大。精神科医生开出了93%配发给寄养青年的精神药物。在同时接受处方药治疗的患者中,22.2%的人在同一精神药物类别中使用了≥2种药物。

结论

寄养青年经常接受联合精神药物治疗,但其有效性和安全性缺乏实质性证据。

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