Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A1, Canada.
Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Int J Mol Sci. 2022 Feb 4;23(3):1782. doi: 10.3390/ijms23031782.
Psychopathic traits in youth may lead to adult criminal behaviors/psychopathy. The Val158Met polymorphism of catechol-O-methyltransferase () may influence the risk for psychopathy-related behaviors, while acting as a biomarker for predicting treatment response to dopaminergic medications. The literature shows inconsistent findings, making the interpretation of 's role difficult. The aims of this article are (i) to conduct a systematic review to analyze the effects of Val158Met on psychopathic traits in children and adolescents, and (ii) to present new evidence on the developmental trajectory of the association of Val158Met and youth psychopathic traits. For the systematic review, a literature search was conducted using PubMed, EMBASE, OVID Medline and PsychINFO with the search terms for psychopathic traits, Val158Met and age of interest. In our genotype study, the Val158Met genotype of 293 youth with European ancestry was analyzed in association with the psychopathy-related behavior scores from the Child Behavior Checklist and the Psychopathy Screening Device. To examine the potential influence of developmental changes, the sample was split into at or above and below age 13, and analyses were performed in males and females separately. The literature search yielded twenty-eight articles to be included in the systematic review, which demonstrated mixed results on the association depending on environmental factors, sex ratios, age groups and behavioral disorder diagnoses. The results from our genotype study revealed that Met homozygous youth in the below age 13 group and conversely Val carrier youth in the above age 13 group were more likely to display psychopathic traits. To our knowledge, this is the first study to systematically review the effects of Val158Met on psychopathic traits in childhood and adolescence, and to provide new evidence on the changing effects of Val158Met on psychopathy-related behaviors with development. Elucidating the role of the genotype in conjunction with the child versus adolescent stage of development for psychopathic traits may help predict treatment response, and may lead to early intervention and prevention strategies.
青少年时期的精神病态特征可能导致成年后的犯罪行为/精神病态。儿茶酚-O-甲基转移酶（）的 Val158Met 多态性可能会影响与精神病态相关的行为的风险，同时作为预测多巴胺能药物治疗反应的生物标志物。文献中的研究结果不一致，使得对的作用难以解释。本文的目的是（i）进行系统评价，分析 Val158Met 对儿童和青少年精神病态特征的影响，以及（ii）提出关于 Val158Met 与青年精神病态特征关联的发展轨迹的新证据。为了进行系统评价，使用 PubMed、EMBASE、OVID Medline 和 PsychINFO 数据库，使用精神病态特征、Val158Met 和感兴趣的年龄等搜索词进行文献检索。在我们的基因研究中，分析了 293 名具有欧洲血统的年轻人的 Val158Met 基因型与来自儿童行为检查表和精神病态筛查工具的与精神病态相关的行为评分之间的关联。为了研究潜在的发育变化的影响，将样本分为 13 岁及以下和 13 岁以上，并分别在男性和女性中进行分析。文献检索产生了 28 篇文章纳入系统评价，这些研究结果表明，由于环境因素、性别比例、年龄组和行为障碍诊断的不同，关联的结果也存在差异。我们的基因研究结果表明，13 岁以下组中纯合 Met 的青少年和相反地，13 岁以上组中 Val 携带者的青少年更有可能表现出精神病态特征。据我们所知，这是第一项系统评价 Val158Met 对儿童和青少年时期精神病态特征的影响的研究，并提供了关于 Val158Met 对与精神病态相关的行为的发展变化的影响的新证据。阐明基因型与儿童或青少年阶段发展对精神病态特征的作用可能有助于预测治疗反应，并可能导致早期干预和预防策略。
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