Zaki Amna, Abrishami Amir, Wong Jean, Chung Frances F
Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
Can J Anaesth. 2008 Jan;55(1):11-21. doi: 10.1007/BF03017592.
To assess the efficacy of interventions offered to patients in the preoperative clinic to promote long-term (> or = three months) smoking cessation following surgery.
We searched The Cochrane Library, MEDLINE, EMBASE and CINAHL for all randomized controlled trials (RCTs) on smoking-cessation interventions initiated in the preoperative clinic. Trial inclusion, quality assessment, and data extraction were performed independently by two authors. Standard meta-analytic techniques were applied.
Four RCTs (n = 610 patients) were included in the review. Interventions included pharmacotherapy, counseling, educational literature and postoperative telephone follow-up. The follow-up period ranged between three to 12 months with only one RCT following up patients for > one year. Two studies used biochemical methods to validate subjects' self-reporting of smoking cessation at the follow-up assessment. Overall, the interventions were associated with a significantly higher cessation rate vs control at the three to six month follow-up period (pooled odds ratio: 1.58, 95% confidence interval (CI) 1.02-2.45, P value = 0.01, I(2) = 0%). The only trial with longer follow-up period (12 months), however, failed to show any significant difference between the intervention and control groups (odds ratio: 1.05, 95% CI 0.53-2.09, P value = 0.88).
This systematic review suggests that smoking-cessation interventions initiated at the preoperative clinic can increase the odds of abstinence by up to 60% within a three- to six-month follow-up period. To evaluate the possibility of longer abstinence, future trials with at least one-year follow-up are recommended.
评估术前门诊为患者提供的干预措施对促进术后长期(≥3个月)戒烟的效果。
我们检索了Cochrane图书馆、MEDLINE、EMBASE和CINAHL,查找所有关于术前门诊启动的戒烟干预措施的随机对照试验(RCT)。两名作者独立进行试验纳入、质量评估和数据提取。应用标准的荟萃分析技术。
该综述纳入了4项RCT(n = 610例患者)。干预措施包括药物治疗、咨询、教育文献和术后电话随访。随访期为3至12个月,只有1项RCT对患者进行了超过1年的随访。两项研究使用生化方法在随访评估中验证受试者戒烟的自我报告。总体而言,在3至6个月的随访期内,干预措施与对照组相比,戒烟率显著更高(合并比值比:1.58,95%置信区间(CI)1.02 - 2.45,P值 = 0.01,I² = 0%)。然而,唯一一项随访期较长(12个月)的试验未能显示干预组和对照组之间有任何显著差异(比值比:1.05,95% CI 0.53 - 2.09,P值 = 0.88)。
该系统评价表明,术前门诊启动的戒烟干预措施在3至6个月的随访期内可使戒烟几率提高多达60%。为评估更长时间戒烟的可能性,建议未来进行至少1年随访的试验。