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大剂量化疗及自体干细胞移植，不联合巩固放疗作为原发性中枢神经系统淋巴瘤的一线治疗方案

High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system.

作者信息

Illerhaus Gerald, Müller Fabian, Feuerhake Friedrich, Schäfer Arnd-Oliver, Ostertag Christoph, Finke Jürgen

出版信息

Haematologica. 2008 Jan;93(1):147-8. doi: 10.3324/haematol.11771.

DOI:10.3324/haematol.11771
PMID:18166803
Abstract

Thirteen patients (age 38-67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.

摘要

13例原发性中枢神经系统淋巴瘤患者（年龄38 - 67岁）接受了甲氨蝶呤和阿糖胞苷/噻替派诱导化疗，随后接受大剂量卡莫司汀/噻替派和自体干细胞移植。放疗仅限于对化疗未完全缓解的患者。中位随访25个月，3年无病生存率和总生存率为77%。

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