Sukach A N, Petrenko A Iu
Ukr Biokhim Zh (1978). 1991 Nov-Dec;63(6):53-6.
Freezing and thawing have been studied for their effect on the rat hepatocyte detoxication system. Freezing-thawing of hepatocytes in the medium without cryoprotectors is to impair functioning of the biotransformation system of biphenyl, a hydrophobic xenobiotic. It is found that inhibition of the first stage of xenobiotics biotransformation is a result of the loss of pyridine nucleotides and substrates necessary for NADP+ reduction.
已经研究了冷冻和解冻对大鼠肝细胞解毒系统的影响。在没有冷冻保护剂的培养基中对肝细胞进行冻融处理会损害联苯（一种疏水性外源性物质）生物转化系统的功能。研究发现，外源性物质生物转化第一阶段的抑制是由于吡啶核苷酸和NADP+还原所需底物的丧失所致。
