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[脂质体在红细胞裂解过程中与红细胞的相互作用]

[Interaction of liposomes with erythrocytes in the process of their lysis].

作者信息

Primak R G, Maksimov Iu N, Golubov M I, Lebed' O I

出版信息

Ukr Biokhim Zh (1978). 1991 Nov-Dec;63(6):78-83.

PMID:1816689
Abstract

Interaction of phosphatidyl choline liposomes with erythrocytes during spontaneous lysis of the latter has been studied. It is shown that hemoglobin which is released during the lysis of erythrocytes is found by liposomes which in their turn are absorbed on the external erythrocyte surface. In this case the binding of hemoglobin by liposomes takes place with a greater speed than its release during erythrocyte lysis and is accompanied by a change in its conformation. Possibilities of the microcalorimetry methods for studying the interaction of liposomes with erythrocytes under the conditions mentioned above are considered.

摘要

研究了磷脂酰胆碱脂质体与红细胞在后者自发裂解过程中的相互作用。结果表明,红细胞裂解过程中释放的血红蛋白被脂质体捕获,而脂质体又吸附在红细胞外部表面。在这种情况下,脂质体与血红蛋白的结合速度比红细胞裂解过程中血红蛋白的释放速度更快,并且伴随着其构象的变化。还考虑了微量量热法在上述条件下研究脂质体与红细胞相互作用的可能性。

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