Sato Eiju, Yamamoto Shuichi, Ogata Kazuha, Kubota Mariko, Sugawara Takeshi, Mizunoya Satoshi
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan.
Doc Ophthalmol. 2008 Mar;116(2):153-8. doi: 10.1007/s10633-007-9103-8. Epub 2008 Jan 1.
To evaluate the efficacy of radial optic neurotomy (RON) on retinal function in patients with central retinal vein occlusion (CRVO).
Ten eyes of 10 patients with CRVO underwent pars plana vitrectomy and RON. Standardized combined electroretinograms (ERGs) to full-field bright-flash stimuli were recorded preoperatively and, 3 months postoperatively. The best-corrected visual acuity and foveal thickness were also determined, before and 3 months postoperatively.
The mean best-corrected visual acuity and mean foveal thickness were both significantly improved after vitrectomy and RON. The mean amplitudes of a- and b-waves did not change significantly, but the mean b/a wave ratio was increased significantly after vitrectomy and RON. An improvement of the b/a ratio was observed in six eyes, however, an improvement of retinal circulation was confirmed on postoperative fluorescein angiograms in two of these six eyes.
Significant improvements were observed in the b/a wave ratio of the standard combined ERGs after surgery in eyes with CRVO. The improvement of retinal function was most likely due to improved oxygenation of retina caused by vitrectomy and not by RON.
评估放射状视神经切开术（RON）对视网膜中央静脉阻塞（CRVO）患者视网膜功能的疗效。
10例CRVO患者的10只眼接受了玻璃体切除术和RON。术前及术后3个月记录标准化全视野明闪光刺激联合视网膜电图（ERG）。术前及术后3个月还测定了最佳矫正视力和黄斑厚度。
玻璃体切除术和RON术后，平均最佳矫正视力和平均黄斑厚度均显著改善。a波和b波的平均振幅无显著变化，但玻璃体切除术和RON术后b/a波平均比值显著升高。6只眼观察到b/a比值改善，然而，这6只眼中有2只眼术后荧光素血管造影证实视网膜循环改善。
CRVO患者术后标准联合ERG的b/a波比值有显著改善。视网膜功能的改善最可能是由于玻璃体切除术改善了视网膜的氧合，而非RON。
