Sharma Sanjeev, Singh Sanjay K, Pandey Daya S
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, U.P., India.
Inorg Chem. 2008 Feb 4;47(3):1179-89. doi: 10.1021/ic701518e. Epub 2008 Jan 3.
Neutral and cationic mononuclear complexes containing both group 15 and polypyridyl ligands [Ru(kappa3-tptz)(PPh3)Cl2] [1; tptz=2,4,6-tris(2-pyridyl)-1,3,5-triazine], [Ru(kappa3-tptz)(kappa2-dppm)Cl]BF4 [2; dppm=bis(diphenylphosphino)methane], [Ru(kappa3-tptz)(PPh3)(pa)]Cl (3; pa=phenylalanine), [Ru(kappa3-tptz)(PPh3)(dtc)]Cl (4; dtc=diethyldithiocarbamate), [Ru(kappa3-tptz)(PPh3)(SCN)2] (5) and [Ru(kappa3-tptz)(PPh3)(N3)2] (6) have been synthesized. Complex 1 has been used as a metalloligand in the synthesis of homo- and heterodinuclear complexes [Cl2(PPh3)Ru(micro-tptz)Ru(eta6-C6H6)Cl]BF4 (7), [Cl2(PPh3)Ru(mu-tptz)Ru(eta6-C10H14)Cl]PF6 (8), and [Cl2(PPh3)Ru(micro-tptz)Rh(eta5-C5Me5)Cl]BF4 (9). Complexes 7-9 present examples of homo- and heterodinuclear complexes in which a typical organometallic moiety [(eta6-C6H6)RuCl]+, [(eta6-C10H14)RuCl]+, or [(eta5-C5Me5)RhCl]+ is bonded to a ruthenium(II) polypyridine moiety. The complexes have been fully characterized by elemental analyses, fast-atom-bombardment mass spectroscopy, NMR (1H and 31P), and electronic spectral studies. Molecular structures of 1-3, 8, and 9 have been determined by single-crystal X-ray diffraction analyses. Complex 1 functions as a good precursor in the synthesis of other ruthenium(II) complexes and as a metalloligand. All of the complexes under study exhibit inhibitory effects on the Topoisomerase II-DNA activity of filarial parasite Setaria cervi and beta-hematin/hemozoin formation in the presence of Plasmodium yoelii lysate.
含有第15族元素和多吡啶配体的中性和阳离子单核配合物[Ru(κ3 - tptz)(PPh3)Cl2] [1；tptz = 2,4,6 - 三(2 - 吡啶基)-1,3,5 - 三嗪]、[Ru(κ3 - tptz)(κ2 - dppm)Cl]BF4 [2；dppm = 双(二苯基膦基)甲烷]、[Ru(κ3 - tptz)(PPh3)(pa)]Cl (3；pa = 苯丙氨酸)、[Ru(κ3 - tptz)(PPh3)(dtc)]Cl (4；dtc = 二乙基二硫代氨基甲酸盐)、[Ru(κ3 - tptz)(PPh3)(SCN)2] (5)和[Ru(κ3 - tptz)(PPh3)(N3)2] (6)已被合成。配合物1已被用作金属配体用于合成同核和异核配合物[Cl2(PPh3)Ru(μ - tptz)Ru(η6 - C6H6)Cl]BF4 (7)、[Cl2(PPh3)Ru(μ - tptz)Ru(η6 - C10H14)Cl]PF6 (8)和[Cl2(PPh3)Ru(μ - tptz)Rh(η5 - C5Me5)Cl]BF4 (9)。配合物7 - 9展示了同核和异核配合物的实例，其中典型的有机金属部分[(η6 - C6H6)RuCl]+、[(η6 - C10H14)RuCl]+或[(η5 - C5Me5)RhCl]+与钌(II)多吡啶部分相连。这些配合物已通过元素分析、快原子轰击质谱、核磁共振(1H和31P)以及电子光谱研究进行了全面表征。配合物1 - 3、8和9的分子结构已通过单晶X射线衍射分析确定。配合物1在其他钌(II)配合物的合成中作为良好的前体以及作为金属配体发挥作用。所研究的所有配合物在丝状寄生虫Setaria cervi的拓扑异构酶II - DNA活性以及在约氏疟原虫裂解物存在下的β - 血红素/疟原虫色素形成方面均表现出抑制作用。
