Sun Xianfeng, Zhou Le, Li Wei, Zhang Xumu
Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8066, USA.
J Org Chem. 2008 Feb 1;73(3):1143-6. doi: 10.1021/jo702068w. Epub 2008 Jan 3.
A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantioselective synthesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.
探索了一种便捷、多样化的策略，用于合成一系列模块化且可精细调节的C3-TunePhos型手性双膦配体及其在高效钌催化的不对称氢化反应中的应用。在β-甲基手性胺和α-羟基酸衍生物的对映选择性合成中，分别实现了高达97%和99%的对映体过量值。
