用于合成TunePhos型手性双膦配体的便捷发散策略及其在高度对映选择性钌催化氢化反应中的应用。
Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations.
作者信息
Sun Xianfeng, Zhou Le, Li Wei, Zhang Xumu
机构信息
Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8066, USA.
出版信息
J Org Chem. 2008 Feb 1;73(3):1143-6. doi: 10.1021/jo702068w. Epub 2008 Jan 3.
A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantioselective synthesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.
探索了一种便捷、多样化的策略，用于合成一系列模块化且可精细调节的C3-TunePhos型手性双膦配体及其在高效钌催化的不对称氢化反应中的应用。在β-甲基手性胺和α-羟基酸衍生物的对映选择性合成中，分别实现了高达97%和99%的对映体过量值。
Zotero 插件