Rakha E A, El-Sayed M E, Reis-Filho J S, Ellis I O
Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.
Histopathology. 2008 Jan;52(1):67-81. doi: 10.1111/j.1365-2559.2007.02894.x.
Breast cancer is a complex genetic disease characterized by the accumulation of multiple molecular alterations. Routine clinical management of breast cancer relies on clinical and pathological factors, however. These seem insufficient to reflect the whole clinical heterogeneity of tumours and are less than perfectly adapted to each patient. Recent advances in human genome research and high-throughput molecular technologies have made it possible to tackle the molecular complexity of breast cancer and have contributed to the realization that the biological heterogeneity of breast cancer has implications for treatment. Gene expression profiling of breast cancer has been performed using several approaches. This review will describe the details of gene expression profiling of breast cancer, the different approaches and the impact on clinical management.
乳腺癌是一种复杂的遗传性疾病，其特征是多种分子改变的积累。然而，乳腺癌的常规临床管理依赖于临床和病理因素。这些因素似乎不足以反映肿瘤的整体临床异质性，也不完全适用于每个患者。人类基因组研究和高通量分子技术的最新进展使得应对乳腺癌的分子复杂性成为可能，并促使人们认识到乳腺癌的生物学异质性对治疗具有重要意义。乳腺癌的基因表达谱分析已经采用了多种方法。本文将描述乳腺癌基因表达谱分析的细节、不同方法以及对临床管理的影响。
