Philippu A, Pfitscher A, Singewald N
Department of Pharmacodynamics and Toxicology, University of Innsbruck, Austria.
J Neural Transm Suppl. 1991;34:107-12. doi: 10.1007/978-3-7091-9175-0_14.
Determination of the release of catecholamines in the rostral and intermediate aspects of the NTS before, during and after termination of a bilateral carotid occlusion revealed that increases in blood pressure elicited by the occlusion reduce the release rates of noradrenaline and adrenaline, while occlusion-induced decreases in blood pressure diminish the release rate of dopamine. These findings demonstrate that, in response to blood pressure changes elicited by carotid occlusion, in both aspects of the NTS noradrenaline and adrenaline act to increase blood pressure when released from their neurones, while the release of dopamine lowers blood pressure. Noradrenergic neurones of the NTS receive impulses from baroreceptors of carotid sinus and aortic arch.
在双侧颈动脉闭塞前、闭塞期间及闭塞终止后，对延髓孤束核吻侧和中间部分儿茶酚胺释放情况的测定显示，闭塞引起的血压升高会降低去甲肾上腺素和肾上腺素的释放速率，而闭塞引起的血压降低则会减少多巴胺的释放速率。这些发现表明，在应对颈动脉闭塞引起的血压变化时，在延髓孤束核的两个部分，去甲肾上腺素和肾上腺素从其神经元释放时会起到升高血压的作用，而多巴胺的释放则会降低血压。延髓孤束核的去甲肾上腺素能神经元接收来自颈动脉窦和主动脉弓压力感受器的冲动。
