Baker D A, Holte J E, Patankar S V
Printware Incorporated, Minneapolis, MN 55120.
Med Biol Eng Comput. 1991 Sep;29(5):482-8. doi: 10.1007/BF02442318.
The goal of this research is to develop a predictive model with good absolute accuracy for blood-gas exchange devices. The proposed model, unlike existing models, is able to predict gas transfer to blood flowing outside oxygenating fibres without experimental data. The proposed model uses a finite-difference numerical technique to solve computationally two-dimensional gas exchange problems such as gas transfer to blood outside hollow fibres. The model is compared to bovine and human experimental data from the small test cells with microporous polypropylene fibres. The test cell flow rates range from 1 m litre min-1 to 5 m litre min-1 for a 72-fibre device. Shear-augmented oxygen diffusion appears to be present, although good accuracy is obtained with a nonaugmented diffusion model, particularly at lower flows. The maximum deviation of oxygen saturation predicted by a shear-augmented bovine blood model from the experimental regression line was 1.7 per cent.
本研究的目标是开发一种针对血气交换装置具有良好绝对精度的预测模型。与现有模型不同，所提出的模型能够在没有实验数据的情况下预测气体向在氧合纤维外部流动的血液中的传输。所提出的模型使用有限差分数值技术来通过计算解决二维气体交换问题，例如气体向中空纤维外部血液中的传输。该模型与来自带有微孔聚丙烯纤维的小型测试单元的牛和人类实验数据进行了比较。对于一个72纤维装置，测试单元的流速范围为1毫升/分钟至5毫升/分钟。尽管使用非增强扩散模型可获得良好的精度，特别是在较低流速下，但似乎存在剪切增强的氧扩散。由剪切增强的牛血模型预测的氧饱和度与实验回归线的最大偏差为1.7%。
