Wu Zunyou, Luo Wei, Sullivan Sheena G, Rou Keming, Lin Peng, Liu Wei, Ming Zhongqiang
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
AIDS. 2007 Dec;21 Suppl 8:S115-22. doi: 10.1097/01.aids.0000304706.79541.ef.
To evaluate the effectiveness of a needle social marketing strategy to reduce needle sharing and hepatitis C Virus (HCV)/HIV transmission among injecting drug users (IDU) in China.
Two-armed, prospective, community-randomized prevention trial.
Four counties/townships in Guangxi and Guangdong provinces; one randomized to intervention the other to control in each province.
Injecting drug users: 823 (443 intervention, 382 control) at baseline and 852 (415 intervention, 407 control) at the second cross-sectional survey 12 months later.
A needle social marketing programme, including promotion of safe injection norms and increased access to clean needles over a 12 month period.
Cross sectional surveys at baseline and follow-up compared changes in drug using behaviours and HIV and HCV rates in the intervention and control communities.
Needle sharing behaviours were similar in the two groups at baseline (68.4 vs. 67.8%), and dropped significantly to 35.3% in the intervention community and remained relatively stable in the control community (62.3%; P < 0.001). In a subset of cohort of new injectors, the incidence of HCV was significant lower in intervention than in control in both provinces (P < 0.001, P = 0.014) and overall (P < 0.001) but HIV was only significantly lower in intervention in Guangdong (P = 0.011).
Needle social marketing can reduce risky injecting behaviour and HIV/HCV transmission among injecting drug users in China and should be expanded.
评估一项针头社会营销战略在中国减少注射吸毒者共用针头及丙型肝炎病毒（HCV）/艾滋病病毒（HIV）传播的效果。
双臂、前瞻性、社区随机预防试验。
广西和广东省的四个县/乡；每个省份一个随机分配至干预组，另一个分配至对照组。
注射吸毒者：基线时823人（443人干预组，382人对照组），12个月后的第二次横断面调查时有852人（415人干预组，407人对照组）。
一项针头社会营销计划，包括在12个月期间推广安全注射规范并增加清洁针头的获取。
基线和随访时的横断面调查比较了干预组和对照组社区吸毒行为以及HIV和HCV感染率的变化。
两组在基线时共用针头行为相似（68.4%对67.8%），干预组社区该行为显著降至35.3%，而对照组社区保持相对稳定（62.3%；P<0.001）。在新注射吸毒者队列的一个亚组中，两个省份干预组的HCV发病率均显著低于对照组（P<0.001，P=0.014），总体上也是如此（P<0.001），但仅在广东干预组的HIV发病率显著较低（P=0.011）。
针头社会营销可减少中国注射吸毒者的危险注射行为及HIV/HCV传播，应予以推广。
