心脏手术后使用重组凝血因子VIIa控制出血后发生的系统性静脉血栓形成。
Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.
作者信息
Mahmoud Amr, Al-Ruzzeh Sharif, McKeague Helena, Cross Mike
机构信息
Leeds General Infirmary, Leeds LS1 3EX, United Kingdom.
出版信息
Tex Heart Inst J. 2007;34(4):485-8.
Abstract
Recombinant factor VIIa has been licensed in the United Kingdom since 1996 for the control of bleeding in hemophilic patients who are actively bleeding or are about to undergo surgery. Medical practitioners are also applying recombinant factor VIIa toward the control of bleeding in patients without hemophilia. Although the efficacy of recombinant factor VIIa has been shown in many patients, concerns have arisen about the risk of thrombotic adverse events. Herein, we report the case of a 73-year-old woman who underwent major coronary surgery and developed fatal systemic venous thrombosis after recombinant factor VIIa was used in an attempt to control her severe postoperative bleeding. We review the medical literature and discuss the risks of using recombinant factor VIIa to control severe bleeding after cardiac surgery.
摘要
自1996年起，重组凝血因子VIIa在英国已获许可，用于控制正在出血或即将接受手术的血友病患者的出血情况。医学从业者也将重组凝血因子VIIa用于控制非血友病患者的出血。尽管重组凝血因子VIIa在许多患者中已显示出疗效，但人们对血栓形成不良事件的风险产生了担忧。在此，我们报告一例73岁女性患者的病例，该患者接受了重大冠状动脉手术，在使用重组凝血因子VIIa试图控制其严重的术后出血后，发生了致命的全身性静脉血栓形成。我们回顾了医学文献，并讨论了使用重组凝血因子VIIa控制心脏手术后严重出血的风险。
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本文引用的文献
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