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甲型血友病患者自发性深静脉血栓形成:一例报告

Spontaneous deep vein thrombosis in hemophilia A: a case report.

作者信息

Bicer Murat, Yanar Murat, Tuydes Oktay

机构信息

Department of Cardiac Surgery, Kalp Damar Cerrahisi Anabilim Dali Görükle Yerleşkesi, Nilüfer Bursa 16059, Turkey.

出版信息

Cases J. 2009 Sep 11;2:6390. doi: 10.1186/1757-1626-0002-0000006390.

DOI:10.1186/1757-1626-0002-0000006390
PMID:20181150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3444229/
Abstract

Venous thromboembolus is an important cause of hospital acquired morbidity and mortality. Venous thrombosis is a very rare occurrence in patients with haemophilia A. The thrombosis originated from the right main and external iliac veins, and effects the cranial segments of the main, deep and superficial femoral veins as an acute phase thrombus. Neither any local anatomic compression nor any predisposing thrombophilic risk factors were identified. We treated the patient with enoxaparine 1 mg/kg twice a day subcutaneously and then started oral anticoagulation with warfarin.

摘要

静脉血栓栓塞是医院获得性发病和死亡的重要原因。甲型血友病患者发生静脉血栓形成的情况非常罕见。血栓形成起源于右主髂外静脉,并作为急性期血栓影响股总静脉、股深静脉和股浅静脉的头段。未发现任何局部解剖压迫或任何易患血栓形成的危险因素。我们对该患者采用皮下注射依诺肝素1mg/kg,每日两次进行治疗,然后开始使用华法林进行口服抗凝治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fde/3444229/8318266de3e4/1757-1626-0002-0000006390-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fde/3444229/8318266de3e4/1757-1626-0002-0000006390-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fde/3444229/8318266de3e4/1757-1626-0002-0000006390-1.jpg

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本文引用的文献

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Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.心脏手术后使用重组凝血因子VIIa控制出血后发生的系统性静脉血栓形成。
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Non-catheter associated venous thrombosis in hemophilia A and B. A critical review of all reported cases.甲型和乙型血友病中的非导管相关性静脉血栓形成。对所有已报道病例的批判性综述。
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Deep vein thrombosis in a patient with severe haemophilia A.一名重度甲型血友病患者发生深静脉血栓形成。
Haemophilia. 2006 Jan;12(1):87-9. doi: 10.1111/j.1365-2516.2006.01179.x.
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Haemophilia and thrombophilia: an unexpected association!
Haemophilia. 2004 Jul;10(4):319-26. doi: 10.1111/j.1365-2516.2004.00906.x.
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[A common mutation C677T in the 5,10-methyltetrahydrofolate reductase gene is associated to idiopathic deep venous thrombosis].5,10-亚甲基四氢叶酸还原酶基因常见的C677T突变与特发性深静脉血栓形成相关
Rev Med Interne. 2003 Sep;24(9):569-76. doi: 10.1016/s0248-8663(03)00210-8.
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Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A.
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Simultaneous deep venous thrombosis and acquired factor VIII inhibitor.同时发生的深部静脉血栓形成和获得性凝血因子 VIII 抑制剂
Clin Appl Thromb Hemost. 2002 Oct;8(4):375-9. doi: 10.1177/107602960200800410.
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