Singh Anjana, Blank Miri, Shoenfeld Yehuda, Illges Harald
Department of Natural Sciences, Immunology and Cell Biology, University of Applied Sciences, von-Liebig-Str. 20, 53359 Rheinbach, Germany.
Rheumatol Int. 2008 May;28(7):661-5. doi: 10.1007/s00296-007-0503-6. Epub 2008 Jan 3.
A soluble form of the complement receptor CD21 (sCD21) is shed from the lymphocyte surface. The sCD21 is able to bind all known ligands such as CD23, sCD23, Epstein-Barr virus and C3d in immune complexes. Here, we show the serum levels of sCD21 in sera the of antiphospholipid syndrome (APS) patients. Antiphospholipid syndrome is an autoimmune disorder in which autoantibodies cause heart attack, stroke and miscarriage. Antiphospholipid syndrome may appear as primary or in association with systemic lupus erythromatosus (SLE) and other autoimmune diseases. Here, we ask whether APS patients have different sCD21 titers compared to healthy persons and whether sCD21 levels correlate with the presence of anti-beta2-GPI autoantibodies. We show that autoimmune APS patients have significantly reduced amounts of sCD21 in their sera, irrespective of the presence of anti-beta2-GPI autoantibodies. In our APS patients cohort additional SLE, vasculities, DVT (deep vein thrombosis), fetal loss or thrombosis did not correlate to the reduced level of sCD21.
补体受体CD21的可溶性形式（sCD21）从淋巴细胞表面脱落。sCD21能够结合免疫复合物中所有已知的配体，如CD23、可溶性CD23、爱泼斯坦-巴尔病毒和C3d。在此，我们展示了抗磷脂综合征（APS）患者血清中sCD21的水平。抗磷脂综合征是一种自身免疫性疾病，其中自身抗体可导致心脏病发作、中风和流产。抗磷脂综合征可能表现为原发性，或与系统性红斑狼疮（SLE）及其他自身免疫性疾病相关。在此，我们探究APS患者与健康人相比sCD21滴度是否不同，以及sCD21水平是否与抗β2-糖蛋白I自身抗体的存在相关。我们发现，自身免疫性APS患者血清中的sCD21含量显著降低，无论是否存在抗β2-糖蛋白I自身抗体。在我们的APS患者队列中，额外的SLE、血管炎、深静脉血栓形成（DVT）、胎儿丢失或血栓形成与sCD21水平降低均无关联。
