Weiss Jocelyn M, Huang Wen-Yi, Rinaldi Sabina, Fears Thomas R, Chatterjee Nilanjan, Hsing Ann W, Crawford E David, Andriole Gerald L, Kaaks Rudolf, Hayes Richard B
Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA.
Int J Cancer. 2008 May 15;122(10):2345-50. doi: 10.1002/ijc.23326.
Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in epidemiologic studies. We conducted a nested case-control study with prospectively collected samples in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, to examine associations of prostate cancer with androstenedione (Delta4-A), testosterone (T), sex hormone-binding globulin (SHBG) and 3alpha-androstanediol glucuronide (3alpha-diolG). A total of 727 incident Caucasian prostate cancer cases (age >/= 65 years, N = 396) and 889 matched controls were selected for this analysis. Overall, prostate cancer risks were unrelated to serum T, estimated free and bioavailable T, and SHBG; however, risks increased with increasing T:SHBG ratio (p(trend) = 0.01), mostly related to risk in older men (>/=65 years, p(trend) = 0.001), particularly for aggressive disease [highest versus lowest quartile: odds ratio (OR) 2.76, 95% confidence interval (CI) 1.50-5.09]. No clear patterns were noted for Delta4-A and 3alpha-diolG. In summary, our large prospective study did not show convincing evidence of a relationship between serum sex hormones and prostate cancer. T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc.
性类固醇激素通过在前列腺细胞增殖、分化和凋亡中的作用来影响前列腺的发育和维持。尽管怀疑其与前列腺癌发生有关，但在流行病学研究中，循环雄激素与前列腺癌之间的关联尚未明确确立。我们在前列腺、肺、结肠直肠和卵巢（PLCO）癌症筛查试验中，利用前瞻性收集的样本进行了一项巢式病例对照研究，以检验前列腺癌与雄烯二酮（Δ4 - A）、睾酮（T）、性激素结合球蛋白（SHBG）和3α - 雄烷二醇葡萄糖醛酸苷（3α - 二醇G）之间的关联。本分析共选取了727例白人前列腺癌新发病例（年龄≥65岁，N = 396）和889例匹配对照。总体而言，前列腺癌风险与血清T、估计的游离和生物可利用T以及SHBG无关；然而，风险随T:SHBG比值升高而增加（p趋势 = 0.01），主要与老年男性（≥65岁，p趋势 = 0.001）的风险相关，特别是侵袭性疾病[最高四分位数与最低四分位数相比：比值比（OR）2.76，95%置信区间（CI）1.50 - 5.09]。对于Δ4 - A和3α - 二醇G未发现明确模式。总之，我们的大型前瞻性研究未显示血清性激素与前列腺癌之间存在令人信服的关系。T:SHBG比值与该老年男性人群的风险相关，但该比值在甾体生物学中的意义尚不清楚。（c）2008 Wiley - Liss，Inc.
