Arslanagić Amila, Bajraktarević Azra
Klinika za bolesti srca I reumatizam, Klinicki centar Univerziteta Sarajevo, Bolnicka .
Med Arh. 2006;60(6 Suppl 2):71-3.
The aim of the study is an echocardiographic assessment of the influence of a long-term lisinopril treatment in combination with amlodipine in patients with LV hypertrophy.
In a clinical prospective study that lasted for 12 months, there were 20 subjects included whose blood pressure was under control. Prior to and after 12 months, there was an assessment of treatment efficacy through determining the values of blood pressure, cardiac frequency and echocardiographic examination of the heart, while the safety of administration was assessed based on the laboratorial blood and urine analysis and monitoring of undesirable effects.
Systolic and diastolic blood pressure remained stabile with preserved cardiac frequency. Echocardiographic findings have shown that EF remained intact, and E/A value improved from 0.89 +/- 0.26 to 1.03 +/- 0.61. There were changes in LVMI for 9.3 +/- 1.45 g/m2.
Myocardial function remained preserved even after 2.5 years of treatment with amlodipine and lisinopril, in combination, with good tolerance.
本研究的目的是通过超声心动图评估长期使用赖诺普利联合氨氯地平治疗对左心室肥厚患者的影响。
在一项为期12个月的临床前瞻性研究中，纳入了20名血压得到控制的受试者。在12个月前后，通过测定血压、心率值以及心脏超声心动图检查来评估治疗效果，同时基于实验室血液和尿液分析以及对不良反应的监测来评估给药安全性。
收缩压和舒张压保持稳定，心率维持正常。超声心动图检查结果显示射血分数（EF）保持不变，E/A值从0.89±0.26改善至1.03±0.61。左心室质量指数（LVMI）变化了9.3±1.45g/m²。
联合使用氨氯地平和赖诺普利治疗2.5年后，心肌功能仍得以保留，且耐受性良好。
