Raza Shahid, Ullah Khalil, Ahmed Parvez, Satti Tariq Mahmood, Kamal Muhammad Khalid, Chaudhry Qamar-un-Nisa
Armed Forces Bone Marrow Transplant Centre, Rawalpindi.
J Pak Med Assoc. 2007 Dec;57(12):611-3.
Neurological complications are quite frequent in stem cell transplant (SCT) recipients. Major causes are conditioning regimen toxicity, metabolic and electrolyte disturbances, viral infections and cyclosporine related toxicity. Cyclosporine induced neurotoxicity is a well documented complication in stem cell transplant recipients. These patients usually present with seizures which are easily controlled with anti-convulsants and by reducing/withholding the drug. However uncontrolled seizures requiring ventilatory support are rarely reported. Here we present a case report of cyclosporine induced uncontrolled seizures in a young female after allogeneic SCT which was unresponsive to anti-convulsive therapy but was successfully treated with mechanical ventilatory support.
神经并发症在干细胞移植（SCT）受者中相当常见。主要原因包括预处理方案毒性、代谢和电解质紊乱、病毒感染以及环孢素相关毒性。环孢素诱导的神经毒性是干细胞移植受者中一种有充分文献记载的并发症。这些患者通常会出现癫痫发作，通过使用抗惊厥药物以及减少/停用该药物可轻松控制发作。然而，需要通气支持的未控制癫痫发作很少有报道。在此，我们报告一例年轻女性在异基因干细胞移植后发生环孢素诱导的未控制癫痫发作的病例，该发作对抗惊厥治疗无反应，但通过机械通气支持成功得到治疗。
