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本文引用的文献

1
Corneal keratocyte deficits after photorefractive keratectomy and laser in situ keratomileusis.准分子激光角膜切削术和准分子激光原位角膜磨镶术后角膜基质细胞缺损
Am J Ophthalmol. 2006 May;141(5):799-809. doi: 10.1016/j.ajo.2005.12.014. Epub 2006 Mar 20.
2
Assessment of stromal keratocytes and tear film inflammatory mediators during extended wear of contact lenses.隐形眼镜长期佩戴期间基质角膜细胞和泪膜炎症介质的评估。
Cornea. 2006 Jan;25(1):1-10. doi: 10.1097/01.ico.0000167877.11687.7e.
3
Comparison of corneal endothelial cell images from a noncontact specular microscope and a scanning confocal microscope.非接触式角膜内皮显微镜与扫描共聚焦显微镜采集的角膜内皮细胞图像比较。
Cornea. 2005 Nov;24(8):980-4. doi: 10.1097/01.ico.0000159737.68048.97.
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Keratocyte density: comparison of two confocal microscopes.
Eye Contact Lens. 2005 Jan;31(1):28-33. doi: 10.1097/01.icl.0000151948.92593.c3.
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Corneal cell density measurement in vivo by scanning slit confocal microscopy: method and validation.
Ophthalmic Res. 2004 Sep-Oct;36(5):270-6. doi: 10.1159/000081207.
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[In vivo confocal corneal microscopy after keratoplasty].
Ophthalmologe. 2005 Feb;102(2):140-6. doi: 10.1007/s00347-004-1083-4.
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On the etiology of keratocyte loss during contact lens wear.关于隐形眼镜佩戴过程中角膜细胞损失的病因学。
Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3011-20. doi: 10.1167/iovs.04-0129.
8
Long-term keratocyte deficits in the corneal stroma after LASIK.准分子激光原位角膜磨镶术后角膜基质中长期存在的角膜细胞缺陷。
Ophthalmology. 2004 Jul;111(7):1356-61. doi: 10.1016/j.ophtha.2003.10.027.
9
Keratocyte reflectivity and corneal haze.角膜细胞反射率与角膜混浊
Exp Eye Res. 2004 Mar;78(3):553-60. doi: 10.1016/s0014-4835(03)00208-2.
10
Corneal wound healing after photorefractive keratectomy: a 3-year confocal microscopy study.准分子激光角膜切削术后角膜伤口愈合：一项为期3年的共聚焦显微镜研究。
Trans Am Ophthalmol Soc. 2003;101:293-333.

角膜基质临床共聚焦显微镜检查中角膜细胞密度的自动评估

Automated assessment of keratocyte density in clinical confocal microscopy of the corneal stroma.

作者信息

McLaren J W, Patel S V, Nau C B, Bourne W M

机构信息

Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

出版信息

J Microsc. 2008 Jan;229(Pt 1):21-31. doi: 10.1111/j.1365-2818.2007.01870.x.

DOI:10.1111/j.1365-2818.2007.01870.x
PMID:18173641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2700340/
Abstract

Cell density in the corneal stroma is typically determined by counting the number of bright objects, presumably keratocyte nuclei, in images from clinical confocal microscopy. We present a program that identifies bright objects and counts those that most likely represent cells. Selection variables were determined from 125 normal corneas with cell densities that had been assessed manually. The program was tested on 17 corneas of patients before and at several intervals to 5 years after laser in situ keratomileusis (LASIK) surgery. In these corneas, which showed a decrease in cell density after surgery, the program identified cells as well as human observers did.

摘要

角膜基质中的细胞密度通常是通过在临床共聚焦显微镜图像中计数明亮物体（推测为角膜细胞细胞核）的数量来确定的。我们提出了一个程序，该程序可以识别明亮物体并对最有可能代表细胞的物体进行计数。选择变量是从125个细胞密度已通过手动评估的正常角膜中确定的。该程序在17例接受准分子原位角膜磨镶术（LASIK）手术的患者的角膜上进行了术前及术后数年（至5年）几个时间点的测试。在这些术后细胞密度降低的角膜中，该程序识别细胞的能力与人类观察者相当。