Misra V S, Saxena V K
Pol J Pharmacol Pharm. 1976;28(3):301-4.
The authors in all have synthesised 28 new N-substituted 2-nitro, 4,5-dimethoxy-benzamides, and anils of 2-amino-3-methoxy and 2-amino-4,5-dimethoxybenzoic acids with a view to obtain potent amoebicides. Their work is based on the observation that a large number of dimethoxyphenyl substituted derivatives occupy an important place as antiamobic agents. Fourteen belonging to different series subjected to in vitro screening for amoebicidal activity against E. histolytica failed to show any significant activity.
作者们总共合成了28种新的N-取代的2-硝基、4,5-二甲氧基苯甲酰胺，以及2-氨基-3-甲氧基和2-氨基-4,5-二甲氧基苯甲酸的缩苯胺，以期获得有效的杀阿米巴剂。他们的工作基于这样的观察，即大量二甲氧基苯基取代的衍生物作为抗阿米巴剂占据重要地位。对属于不同系列的14种化合物进行了针对溶组织内阿米巴的杀阿米巴活性的体外筛选，但未显示出任何显著活性。
