动脉瘤性蛛网膜下腔出血后脑血管痉挛的分子机制。

Molecular mechanisms of cerebral vasospasm following aneurysmal SAH.

作者信息

Rothoerl Ralf Dirk, Ringel Florian

机构信息

Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

出版信息

Neurol Res. 2007 Oct;29(7):636-42. doi: 10.1179/016164107X240224.

DOI:10.1179/016164107X240224

PMID:18173899

Abstract

Cerebral vasospasm following aneurysmal vasospasm has been the subject of intensive research. However the underlying pathophysiological mechanisms remain obscure. This article should summarize the present state concerning smooth muscle contraction, endothelial dysfunction, inflammatory changes, gene expression, in the genesis of vasospasm following aneurysmal subarachnoid hemorrhage.

摘要

动脉瘤性蛛网膜下腔出血后的脑血管痉挛一直是深入研究的课题。然而，其潜在的病理生理机制仍不清楚。本文将总结动脉瘤性蛛网膜下腔出血后血管痉挛发生过程中平滑肌收缩、内皮功能障碍、炎症变化、基因表达等方面的现状。