Shishov M, Henrickson M, Burgos-Vargas R, Rubio-Pérez N, Baca V, Romero-Feregrino R, Solís-Vallejo E, Huang B, Grom A A, Lovell D J
Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Clin Exp Rheumatol. 2007 Nov-Dec;25(6):907-14.
To investigate if the persistence of systemic features is longer in Hispanic children with systemic juvenile idiopathic arthritis (S-JIA) than in non-Hispanic children with S-JIA and to determine early predictors of systemic and articular disease.
We performed a multi-center retrospective chart review of patients followed in six pediatric rheumatology centers with onset of S-JIA from 1974 to 2004. Patients were included in the study if they had been followed for > or = 1 year after disease onset. Information collected included demographic, clinical, laboratory and treatment data. Systemic features included fever, rash, lymphadenopathy, hepatosplenomegaly, pericarditis, and pleuritis.
Of the 159 S-JIA patients screened, 120 (75%) met our inclusion criteria. There were 65 boys and 55 girls. The mean follow-up period for Hispanic patients was 5.7 years (SD 4.0) and for non-Hispanic patients was 8.6 years (SD 7.2). There was no significant difference in the presence of systemic features between Hispanic and non-Hispanic patients at 0.5, 1, 2, 4, 6, 8, and 10 years of follow-up. Polyarthritis at the 6-month visit was predictive of systemic features (OR 9.7, 95% CI 1.16-81.35, p = 0.036) and polyarthritis (OR 5.6, 95% CI 1.42-21.8, p = 0.014) at last follow-up.
In children with S-JIA, Hispanics did not demonstrate longer persistence of systemic features than non-Hispanics. Polyarthritis at 6 months strongly predicted the development of persistent systemic features and chronic polyarticular disease.
研究患有全身型幼年特发性关节炎（S-JIA）的西班牙裔儿童的全身症状持续时间是否比非西班牙裔S-JIA儿童更长，并确定全身和关节疾病的早期预测因素。
我们对1974年至2004年在六个儿科风湿病中心确诊为S-JIA的患者进行了多中心回顾性病历审查。如果患者在疾病发作后随访时间≥1年，则纳入本研究。收集的信息包括人口统计学、临床、实验室和治疗数据。全身症状包括发热、皮疹、淋巴结病、肝脾肿大、心包炎和胸膜炎。
在筛选的159例S-JIA患者中，120例（75%）符合我们的纳入标准。其中男孩65例，女孩55例。西班牙裔患者的平均随访期为5.7年（标准差4.0），非西班牙裔患者为8.6年（标准差7.2）。在随访的0.5、1、2、4、6、8和10年时，西班牙裔和非西班牙裔患者的全身症状出现情况无显著差异。6个月时出现多关节炎可预测最后一次随访时的全身症状（比值比9.7，95%可信区间1.16-81.35，p=0.036）和多关节炎（比值比5.6，95%可信区间1.42-21.8，p=0.014）。
在患有S-JIA的儿童中，西班牙裔患者的全身症状持续时间并不比非西班牙裔患者更长。6个月时出现多关节炎强烈预测持续性全身症状和慢性多关节疾病的发生。
