Nagakane Yoshinari, Yamada Kei, Ohara Tomoyuki, Yoshikawa Kenji, Kuriyama Nagato, Takayasu Natsuko, Kasai Takashi, Yuki Natsuko, Nishimura Tsunehiko, Mizuno Toshiki, Nakagawa Masanori
Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.
Stroke. 2008 Feb;39(2):494-6. doi: 10.1161/STROKEAHA.107.484337. Epub 2008 Jan 3.
Symptomatic progression is frequently observed in lacunar infarcts. The exact mechanisms of this phenomenon have not yet been clarified.
We report 2 patients with lenticulostriate artery infarcts that presented with skip lesions that were restricted to gray matter. One of the patients subsequently developed symptomatic deterioration; the other experienced no further neurological events.
A possible mechanism of differential vulnerability to ischemia of gray and white matter is considered. White matter may have a longer therapeutic time window for neuroprotective treatment than gray matter.