Williams Janet B W, Kobak Kenneth A
Biometrics Research Unit, Columbia University, New York, New York, USA.
Br J Psychiatry. 2008 Jan;192(1):52-8. doi: 10.1192/bjp.bp.106.032532.
The Montgomery-Asberg Depression Rating Scale (MADRS) is often used in clinical trials to select patients and to assess treatment efficacy. The scale was originally published without suggested questions for clinicians to use in gathering the information necessary to rate the items. Structured and semi-structured interview guides have been found to improve reliability with other scales.
To describe the development and test-retest reliability of a structured interview guide for the MADRS (SIGMA).
A total of 162 test-retest interviews were conducted by 81 rater pairs. Each patient was interviewed twice, once by each rater conducting an independent interview.
The intraclass correlation for total score between raters using the SIGMA was r=0.93, P<0.0001. All ten items had good to excellent interrater reliability.
Use of the SIGMA can result in high reliability of MADRS scores in evaluating patients with depression.
蒙哥马利-奥斯伯格抑郁评定量表（MADRS）常用于临床试验中筛选患者和评估治疗效果。该量表最初发布时未提供供临床医生用于收集评定项目所需信息的建议问题。已发现结构化和半结构化访谈指南可提高与其他量表相关的可靠性。
描述蒙哥马利-奥斯伯格抑郁评定量表结构化访谈指南（SIGMA）的开发及重测信度。
81对评分者共进行了162次重测访谈。每位患者接受两次访谈，每次由一名评分者进行独立访谈。
使用SIGMA的评分者之间总分的组内相关系数为r = 0.93，P < 0.0001。所有十个项目的评分者间信度均良好至优秀。
使用SIGMA在评估抑郁症患者时可使MADRS评分具有高可靠性。
