Sharma Rajni, Seth Rachna, Thavaraj V, Bagga A, Kabra S K, Karak A K, Atri S
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Indian J Pediatr. 2007 Dec;74(12):1116-20. doi: 10.1007/s12098-007-0210-z.
Castleman's disease is an atypical lymphoproliferative disorder having two types of presentation--the localized and the multicentric form. The localized form presents as a slowly growing mass with a relatively benign course. Multicentric Castleman's disease has a more aggressive clinical course with diffuse lymph node enlargement and systemic illness. It is rarely seen in childhood and only thirteen cases have been reported in literature. This is the first report of 2 cases from the Indian subcontinent with a maximum follow-up of 44 months one of whom had asplenia.
卡斯尔曼病是一种非典型的淋巴增生性疾病，有两种表现形式——局限性和多中心型。局限性形式表现为缓慢生长的肿块，病程相对良性。多中心型卡斯尔曼病临床病程更具侵袭性，伴有弥漫性淋巴结肿大和全身症状。它在儿童期很少见，文献中仅报道过13例。这是来自印度次大陆的2例病例的首次报告，最长随访时间为44个月，其中1例无脾。
