Meurer Michael, Lubbe Jann, Kapp Alexander, Schneider Dirk
Department of Dermatology, Universitatsklinikum Dresden, Dresden, Germany.
Dermatology. 2007;215 Suppl 1:18-26. doi: 10.1159/000102117. Epub 2007 Dec 18.
In approximately 60% of patients atopic eczema starts in early childhood and persists throughout adolescence. The inadequate treatment of adult patients with recurrent flaring atopic eczema is associated with poor symptom control and diminished quality of life. The prolonged continuous use of topical corticosteroids is not advocated because of the risk of local and systemic adverse events. Pimecrolimus cream 1% (Elidel) is an alternative to topical corticosteroids, particularly for delicate skin, e.g. face and other sensitive skin areas, because it has no atrophogenic potential. The results from clinical trials in adult patients demonstrate that intermittent treatment with pimecrolimus relieves the acute symptoms of atopic eczema and improves disease control and quality of life in the long term.
约60%的特应性皮炎患者在幼儿期发病，并持续至青春期。成年复发性特应性皮炎患者治疗不当与症状控制不佳和生活质量下降有关。由于存在局部和全身不良事件风险，不提倡长期连续使用外用糖皮质激素。1%吡美莫司乳膏（爱宁达）是外用糖皮质激素的替代药物，尤其适用于娇嫩皮肤，如面部和其他敏感皮肤区域，因为它没有致萎缩的风险。成年患者的临床试验结果表明，吡美莫司间歇治疗可缓解特应性皮炎的急性症状，并从长期改善疾病控制和生活质量。
