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Mouse models for understanding the growth hormone insulin-like growth factor-I axis.

作者信息

Rosen Clifford J

机构信息

Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Me. 04401, USA.

出版信息

Horm Res. 2007;68 Suppl 5:2-4. doi: 10.1159/000110461. Epub 2007 Dec 10.

DOI:10.1159/000110461
PMID:18174693
Abstract

BACKGROUND

Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass.

CONCLUSIONS

Mouse models continue to deepen our understanding of IGF-I signaling and the role of IGF-I in determining marrow stromal cell fate.

摘要

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