细胞色素氧化酶模型。
A model for cytochrome oxidase.
作者信息
Palmer G, Babcock G T, Vickery L E
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2206-10. doi: 10.1073/pnas.73.7.2206.
Abstract
A model is proposed for the active center of cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) in which cytochrome a is a low-spin ferrihemoprotein and cytochrome a3 is a high-spin ferrihemoprotein antiferromagnetically coupled to one of the two Cu2+ ions present in the enzyme. It is further proposed that reduction is accompanied by a conformational change in the enzyme thus exposing the sixth coordination site of cytochrome a3 to ligands. With this model it is possible to account for a variety of outstanding observations including the results of magnetic circular dichroism, Mossbauer, and electron paramagnetic resonance spectroscopies, as well as magnetic susceptibility measurements.
摘要
提出了一种细胞色素c氧化酶（亚铁细胞色素c：氧氧化还原酶，EC 1.9.3.1）活性中心的模型，其中细胞色素a是低自旋高铁血红蛋白，细胞色素a3是高自旋高铁血红蛋白，与酶中存在的两个Cu2+离子之一反铁磁耦合。进一步提出，还原过程伴随着酶的构象变化，从而使细胞色素a3的第六个配位位点暴露于配体。基于该模型，可以解释各种突出的观察结果，包括磁圆二色性、穆斯堡尔和电子顺磁共振光谱的结果，以及磁化率测量结果。
相似文献
1
A model for cytochrome oxidase.细胞色素氧化酶模型。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2206-10. doi: 10.1073/pnas.73.7.2206.
2
Cytochrome oxidase: an alternative model.细胞色素氧化酶：一种替代模型。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1806-8. doi: 10.1073/pnas.77.4.1806.
3
Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.一氧化氮结合研究揭示的细胞色素c氧化酶中细胞色素a3-Cua3偶联物的结构
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3320-4. doi: 10.1073/pnas.76.7.3320.
4
Electronic state of heme in cytochrome oxidase III. The magnetic susceptibility of beef heart cytochrome oxidase and some of its derivatives from 7-200 K. Direct evidence for an antiferromagnetically coupled Fe (III)/Cu (II) pair.细胞色素氧化酶III中血红素的电子态。牛心细胞色素氧化酶及其某些衍生物在7 - 200 K的磁化率。反铁磁耦合的Fe(III)/Cu(II)对的直接证据。
J Biol Chem. 1978 Nov 25;253(22):8065-71.
5
Low-spin ferric forms of cytochrome a3 in mixed-ligand and partially reduced cyanide-bound derivatives of cytochrome c oxidase.细胞色素c氧化酶混合配体及部分还原的氰化物结合衍生物中细胞色素a3的低自旋铁形式
Biochem J. 1983 Oct 1;215(1):57-66. doi: 10.1042/bj2150057.
6
Effect of high pH on the spectral and catalytic properties of beef heart cytochrome oxidase.高pH值对牛心细胞色素氧化酶光谱和催化特性的影响。
Biochemistry. 1987 Jun 2;26(11):3038-44. doi: 10.1021/bi00385a014.
7
Determination of the optical properties of CuA(II) in bovine cytochrome c oxidase using magnetic circular dichroism as an optical detector of paramagnetic resonance.使用磁圆二色性作为顺磁共振的光学探测器测定牛细胞色素c氧化酶中CuA(II)的光学性质。
J Inorg Biochem. 1986 Oct-Nov;28(2-3):195-205. doi: 10.1016/0162-0134(86)80083-6.
8
Copper electron-nuclear double resonance of cytochrome c oxidase.细胞色素c氧化酶的铜电子-核双共振
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1452-6. doi: 10.1073/pnas.77.3.1452.
9
The structure of the cytochrome a3-CuB site of mammalian cytochrome c oxidase as probed by MCD and EPR spectroscopy.通过磁圆二色光谱和电子顺磁共振光谱探测的哺乳动物细胞色素c氧化酶的细胞色素a3-CuB位点结构。
J Inorg Biochem. 1985 Mar-Apr;23(3-4):187-97. doi: 10.1016/0162-0134(85)85025-x.
10
Cyanide inhibition of cytochrome c oxidase. A rapid-freeze e.p.r. investigation.氰化物对细胞色素c氧化酶的抑制作用。快速冷冻电子顺磁共振研究。
Biochem J. 1984 Dec 15;224(3):829-37. doi: 10.1042/bj2240829.
引用本文的文献
1
Insight into the active-site structure and function of cytochrome oxidase by analysis of site-directed mutants of bacterial cytochrome aa3 and cytochrome bo.通过分析细菌细胞色素aa3和细胞色素bo的定点突变体深入了解细胞色素氧化酶的活性位点结构与功能。
J Bioenerg Biomembr. 1993 Apr;25(2):121-36. doi: 10.1007/BF00762854.
2
Low-spin ferric forms of cytochrome a3 in mixed-ligand and partially reduced cyanide-bound derivatives of cytochrome c oxidase.细胞色素c氧化酶混合配体及部分还原的氰化物结合衍生物中细胞色素a3的低自旋铁形式
Biochem J. 1983 Oct 1;215(1):57-66. doi: 10.1042/bj2150057.
3
Spectroscopic characterization of compound C and related derivatives of cytochrome oxidase.细胞色素氧化酶的化合物C及相关衍生物的光谱表征
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1652-5. doi: 10.1073/pnas.78.3.1652.
4
Studies on the resolution of cytochrome oxidase.细胞色素氧化酶的分辨率研究。
J Bioenerg Biomembr. 1981 Apr;13(1-2):61-87. doi: 10.1007/BF00744747.
5
Characterization of the intermediates in the reaction of mixed-valence state soluble cytochrome oxidase with oxygen at low temperatures by optical and electron-paramagnetic-resonance spectroscopy.利用光学和电子顺磁共振光谱对混合价态可溶性细胞色素氧化酶在低温下与氧气反应的中间体进行表征。
Biochem J. 1980 Jan 1;185(1):155-67. doi: 10.1042/bj1850155.
6
Characterization of the low-temperature intermediates of the reaction of fully reduced soluble cytochrome oxidase with oxygen by electron-paramagnetic-resonance and optical spectroscopy.通过电子顺磁共振和光谱学对完全还原的可溶性细胞色素氧化酶与氧气反应的低温中间体进行表征。
Biochem J. 1980 Jan 1;185(1):139-54. doi: 10.1042/bj1850139.
7
Cytochrome oxidase: an alternative model.细胞色素氧化酶：一种替代模型。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1806-8. doi: 10.1073/pnas.77.4.1806.
8
Nucleotide sequence of the cybB gene encoding cytochrome b561 in Escherichia coli K12.大肠杆菌K12中编码细胞色素b561的cybB基因的核苷酸序列。
Mol Gen Genet. 1988 Apr;212(1):1-5. doi: 10.1007/BF00322437.
9
An analysis of the reaction kinetics of the hexahaem nitrite reductase of the anaerobic rumen bacterium Wolinella succinogenes.厌氧瘤胃细菌琥珀酸沃林氏菌六血红素亚硝酸还原酶的反应动力学分析。
Biochem J. 1990 Oct 15;271(2):457-61. doi: 10.1042/bj2710457.
10
Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.一氧化氮结合研究揭示的细胞色素c氧化酶中细胞色素a3-Cua3偶联物的结构
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3320-4. doi: 10.1073/pnas.76.7.3320.
本文引用的文献
1
VALENCE STATE OF COPPER AFTER INTERACTION OF THE CYTOCHROME OXIDASE-CARBON MONOXIDE COMPLEX WITH FERRICYANIDE.细胞色素氧化酶 - 一氧化碳复合物与铁氰化物相互作用后铜的价态
Biochim Biophys Acta. 1964 Dec 23;92:607-9. doi: 10.1016/0926-6569(64)90022-7.
2
Reactions of cytochrome oxidase with oxygen and carbon monoxide.细胞色素氧化酶与氧气和一氧化碳的反应。
Biochem J. 1963 Mar;86(3):541-54. doi: 10.1042/bj0860541.
3
Properties of the copper associated with cytochrome oxidase as studied by paramagnetic resonance spectroscopy.通过顺磁共振光谱研究与细胞色素氧化酶相关的铜的性质。
J Biol Chem. 1962 Jul;237:2337-46.
4
Cupric ion in blue proteins.蓝色蛋白质中的铜离子。
J Chem Phys. 1968 May 15;48(10):4398-404. doi: 10.1063/1.1668007.
5
Reaction of cytochrome C oxidase with CO: involvement of the invisible copper.细胞色素C氧化酶与一氧化碳的反应：不可见铜的作用
FEBS Lett. 1974 Nov 1;48(1):45-9. doi: 10.1016/0014-5793(74)81058-6.
6
Heme-heme interaction in cytochrome c oxidase: the cooperativity of the hemes of cytochrome c oxidase as evidenced in the reaction with CO.细胞色素c氧化酶中的血红素-血红素相互作用：细胞色素c氧化酶血红素的协同性，如在与CO反应中所证明的那样。
Arch Biochem Biophys. 1974 Feb;160(2):476-86. doi: 10.1016/0003-9861(74)90424-x.
7
Cytochrome c oxidase: some current biochemical and biophysical problems.细胞色素c氧化酶：当前一些生物化学和生物物理学问题
Q Rev Biophys. 1973 Nov;6(4):389-431. doi: 10.1017/s0033583500001578.
8
Persistence of cadmium-induced metabolic changes in liver and kidney.镉诱导的肝脏和肾脏代谢变化的持续性。
Science. 1974 Mar 15;183(4129):1094-6. doi: 10.1126/science.183.4129.1094.
9
Biochemical and biophysical studies on cytochrome c oxidase. XI. Reaction with azide.细胞色素c氧化酶的生化与生物物理研究。XI. 与叠氮化物的反应。
Biochim Biophys Acta. 1973 Oct 19;325(1):1-7. doi: 10.1016/0005-2728(73)90144-8.
10
Evaluation of the energetics of cytochrome C oxidase in the absense of cytochrome C.在缺乏细胞色素C的情况下对细胞色素C氧化酶能量学的评估。
FEBS Lett. 1973 Nov 1;36(3):326-9. doi: 10.1016/0014-5793(73)80402-8.
Zotero 插件