Kim Dong Soo, Lee Taek Jin, Kang Jin Han, Kim Jong-Hyun, Lee Jung Hyun, Ma Sang Hyuk, Kim Sun Young, Kim Hwang Min, Shin Son Mun
Department of Pediatrics, Yonsei University College of Medicine, Severance Chilfren's Hospital, Seoul, South Korea.
Pediatr Infect Dis J. 2008 Feb;27(2):177-8. doi: 10.1097/INF.0b013e31815aba79.
We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.
我们评估了五价人-牛重配轮状病毒疫苗在178名韩国健康婴儿中的免疫原性和安全性。94名疫苗接种者中血清抗轮状病毒IgA滴度的血清反应率为94.7%，而52名安慰剂接种者中的血清反应率为13.5%。疫苗组中针对疫苗中每种人轮状病毒血清型的血清中和抗体的血清反应率显著高于安慰剂组。这种疫苗总体耐受性良好且具有免疫原性。
