完整人类血小板的转移核欧沃豪斯效应核磁共振实验：RGD肽模拟物的受体结合构象
Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.
作者信息
Potenza Donatella, Belvisi Laura
机构信息
Dipartimento di Chimica Organica e Industriale and Centro Interdisciplinare Studi bio-molecolari e applicazioni Industriali, Università degli Studi di Milano, via G. Venezian 21, I-20133 Milano, Italy.
出版信息
Org Biomol Chem. 2008 Jan 21;6(2):258-62. doi: 10.1039/b713036h. Epub 2007 Nov 29.
The aim of this work is to show that transferred-NOE provides useful and detailed information on membrane-bound receptor-ligand interactions in living cells. Here, we study the interaction between intact human platelets and some ligands containing the RGD sequence. Conformational properties of the free and bound pentapeptides are reported.
这项工作的目的是表明转移核Overhauser效应（transferred-NOE）能为活细胞中膜结合受体-配体相互作用提供有用且详细的信息。在此，我们研究完整的人类血小板与一些含有RGD序列的配体之间的相互作用。报告了游离和结合的五肽的构象性质。
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