丙二腈对α,β-不饱和酮的高度对映选择性迈克尔加成反应。
Highly enantioselective Michael addition of malononitrile to alpha,beta-unsaturated ketones.
作者信息
Li Xuefeng, Cun Lingfeng, Lian Chunxia, Zhong Ling, Chen Yingchun, Liao Jian, Zhu Jin, Deng Jingen
机构信息
National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, The Chinese Academy of Sciences, Chengdu 610041, China.
出版信息
Org Biomol Chem. 2008 Jan 21;6(2):349-53. doi: 10.1039/b713129a. Epub 2007 Dec 3.
The highly enantioselective Michael addition of malononitrile to acyclic and cyclic alpha,beta-unsaturated ketones has been developed. The Michael reaction catalyzed by a primary amine derived from quinidine proceeded smoothly and provided the desired adducts with excellent enantioselectivities (83-97% ee).
已开发出丙二腈对开链和环状α,β-不饱和酮的高度对映选择性迈克尔加成反应。由奎尼丁衍生的伯胺催化的迈克尔反应顺利进行，并以优异的对映选择性（83-97% ee）提供所需的加合物。
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