Li Xuefeng, Cun Lingfeng, Lian Chunxia, Zhong Ling, Chen Yingchun, Liao Jian, Zhu Jin, Deng Jingen
National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, The Chinese Academy of Sciences, Chengdu 610041, China.
Org Biomol Chem. 2008 Jan 21;6(2):349-53. doi: 10.1039/b713129a. Epub 2007 Dec 3.
The highly enantioselective Michael addition of malononitrile to acyclic and cyclic alpha,beta-unsaturated ketones has been developed. The Michael reaction catalyzed by a primary amine derived from quinidine proceeded smoothly and provided the desired adducts with excellent enantioselectivities (83-97% ee).
已开发出丙二腈对开链和环状α,β-不饱和酮的高度对映选择性迈克尔加成反应。由奎尼丁衍生的伯胺催化的迈克尔反应顺利进行，并以优异的对映选择性（83-97% ee）提供所需的加合物。
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