作为全身麻醉作用底物的抑制性配体门控离子通道。
Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.
作者信息
Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grashoff C, Antkowiak B, Rudolph U
机构信息
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
出版信息
Handb Exp Pharmacol. 2008(182):31-51. doi: 10.1007/978-3-540-74806-9_2.
General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.
全身麻醉药已在临床使用超过160年。然而，其作用机制仍未被充分理解。在本综述中，我们描述了一些研究，这些研究表明抑制性配体门控离子通道在体外是全身麻醉药的潜在靶点，并描述了如何通过体内基因研究来证明γ-氨基丁酸（GABA）（A）受体亚型参与麻醉作用。
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