Lee Sung-Ho, Shnitko Tatiana A, Hsu Li-Ming, Broadwater Margaret A, Sardinas Mabelle, Wang Tzu-Wen Winnie, Robinson Donita L, Vetreno Ryan P, Crews Fulton T, Shih Yen-Yu Ian
Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA.
Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA.
Addict Neurosci. 2023 Sep;7. doi: 10.1016/j.addicn.2023.100105. Epub 2023 Jun 2.
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior little is known about how acute alcohol exposure alters large-scale brain networks and how sex and age may moderate such effects. Here, we employ a recently developed functional magnetic resonance imaging (fMRI) protocol to acquire rat brain functional connectivity data and use an established analytical pipeline to examine the effect of sex, age, and alcohol dose on connectivity within and between three major rodent brain networks: defaul mode, salience, and lateral cortical network. We identify the intra- and inter-network connectivity differences and establish moderation models to reveal significant influences of age on acute alcohol-induced lateral cortical network connectivity. Through this work, we make brain-wide isotropic fMRI data with acute alcohol challenge publicly available, with the hope to facilitate future discovery of brain regions/circuits that are causally relevant to the impact of acute alcohol use.
酒精滥用，尤其是青少年饮酒，是一个重大的公共卫生问题。虽然有证据表明青少年饮酒会影响对行为进行认知控制的重要额叶脑区，但对于急性酒精暴露如何改变大规模脑网络以及性别和年龄如何调节这种影响却知之甚少。在这里，我们采用最近开发的功能磁共振成像（fMRI）方案来获取大鼠脑功能连接数据，并使用既定的分析流程来检查性别、年龄和酒精剂量对三个主要啮齿动物脑网络（默认模式、突显和外侧皮质网络）内部和之间连接性的影响。我们确定了网络内和网络间的连接差异，并建立调节模型以揭示年龄对急性酒精诱导的外侧皮质网络连接性的显著影响。通过这项工作，我们公开了急性酒精挑战下全脑各向同性的fMRI数据，希望能促进未来对与急性酒精使用影响有因果关系的脑区/神经回路的发现。
