Kuglík P, Filková H, Oltová A, Hájek R
Katedra genetiky a molekulární biologie Ustavu experimentální biologie Prírodovedecké fakulty MU, Brno.
Vnitr Lek. 2006 Nov;52 Suppl 2:76-8.
Multiple myeloma is a malignant disease caused by malign transformation of B-cells, their clonal proliferation and the accumulation of myeloma cells in the bone marrow. These cells are set apart by a pronounced genetic instability. Chromosomal abnormalities are probably the most important prognostic factors in myeloma which influence the division of the patients into individual sub-groups each with a different developmental process of the disease and thus a different approach during treatment. The study summarizes the methodological approaches and current options in classical and molecular cytogenetics during the examination of cytogenetic changes in multiple myeloma. It presents the most common types of numerical and structural chromosomal changes found in the karyotype of multiple myeloma patients, and their prognostic importance.
多发性骨髓瘤是一种由B细胞恶性转化、克隆性增殖以及骨髓瘤细胞在骨髓中积聚所引起的恶性疾病。这些细胞具有明显的遗传不稳定性。染色体异常可能是骨髓瘤最重要的预后因素，它影响着将患者分为不同的亚组，每个亚组疾病的发展过程不同，因此治疗方法也不同。本研究总结了在检查多发性骨髓瘤细胞遗传学变化时，经典细胞遗传学和分子细胞遗传学的方法及当前的选择。它介绍了在多发性骨髓瘤患者核型中发现的最常见的数值和结构染色体变化类型及其预后重要性。
