[肺癌患者癌性厌食-恶病质综合征中转化生长因子-β和血管内皮生长因子的血清水平分析]

[Serum levels analysis of TGF-Beta and VEGF in patients with cancer anorexia-cachexia syndrome in lung cancer].

作者信息

Kosacka Monika, Weryńska Bozena, Gołecki Marcin, Porebska Irena, Passowicz-Muszyńska Ewa, Jankowska Renata

机构信息

Z Katedry i Kliniki Pulmonologii i Nowotworów Płuc Akademii Medycznej we Wrocławiu.

出版信息

Wiad Lek. 2007;60(7-8):335-40.

PMID:18175552

Abstract

UNLABELLED

The pathogenesis of cancer anorexia-cachexia syndrome (CACS) is very complicated. In development of this syndrome play a role: metabolism of glucose, tumor necrosis factor (TNF), interleukin 1, interleukin 6, interferon a, interferon y, the oncological treatment and many other factors. Vascular endothelial growth factor (VEGF) is the most important proangiogenic factor. It promotes new vessels development, enhances vascular permeability and recruits monocytes. Many factors play a role in regulation of VEGF level. One of the most important is transforming growth factor beta (TGF-beta). Vascular endothelial growth factor and TGF-beta play a role in inflammation reaction too. The aim of this study was the evaluation of correlation between VEGF and TGF-beta in CACS in lung cancer.

MATERIAL AND METHOD

We measured the serum level of VEGF and TGF-beta in 40 patients with lung cancer (20 with and 20 without CACS) and in control group. The serum level was measured by ELISA method.

RESULTS

The correlation between VEGF and TGF-beta was not statistically significant in patients with CACS (p = 0.67), but the statistical significance was in patients without CACS (p = 0.006) and in control group (p = 0.035).

CONCLUSION

Results suggest, that VEGF regulation in CACS may be more complicated.

摘要

未标注

癌症恶病质综合征（CACS）的发病机制非常复杂。在该综合征的发展过程中，葡萄糖代谢、肿瘤坏死因子（TNF）、白细胞介素1、白细胞介素6、干扰素α、干扰素γ、肿瘤治疗及许多其他因素都发挥了作用。血管内皮生长因子（VEGF）是最重要的促血管生成因子。它促进新血管生成，增强血管通透性并募集单核细胞。许多因素在VEGF水平的调节中发挥作用。其中最重要的因素之一是转化生长因子β（TGF-β）。血管内皮生长因子和TGF-β在炎症反应中也发挥作用。本研究的目的是评估肺癌CACS中VEGF与TGF-β之间的相关性。